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Review
. 2025 Mar 4;50(2):112.
doi: 10.1007/s11064-025-04361-7.

Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood-Brain Barrier Integrity

Victória Linden de Rezende  1   2 , Maiara de Aguiar da Costa  1   2 , Carla Damasio Martins  1   2 , Khiany Mathias  1   2   3 , Cinara Ludvig Gonçalves  1   2 , Tatiana Barichello  1   2   4 , Fabricia Petronilho  5   6   7
Affiliations
Review

Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood-Brain Barrier Integrity

Victória Linden de Rezende et al. Neurochem Res. .

Abstract

The aging process results in structural, functional, and immunological changes in the brain, which contribute to cognitive decline and increase vulnerability to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and stroke-related complications. Aging leads to cognitive changes and also affect executive functions. Additionally, it causes neurogenic and neurochemical alterations, such as a decline in dopamine and acetylcholine levels, which also impact cognitive performance. The chronic inflammation caused by aging contributes to the impairment of the blood-brain barrier (BBB), contributing to the infiltration of immune cells and exacerbating neuronal damage. Therefore, rejuvenating therapies such as heterochronic parabiosis, cerebrospinal fluid (CSF) administration, plasma, platelet-rich plasma (PRP), and stem cell therapy have shown potential to reverse these changes, offering new perspectives in the treatment of age-related neurological diseases. This review focuses on highlighting the effects of rejuvenating interventions on neuroinflammation and the BBB.

Keywords: Aging; Blood–brain-barrier; Neuroinflammation; Rejuvenating therapies.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose.

References

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