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. 2025 Apr 8;14(4):piaf019.
doi: 10.1093/jpids/piaf019.

Healthcare-Associated Gastroenteritis: Outbreak Report and Systematic Review of the Literature

Nathan L'Etoile  1   2 , Morgan A Zalot  1 , Salma Sadaf  1 , Nicole Wittmeyer  1 , Anna Davis  1 , Jordan Mick  1 , Ericka Hayes  1   2 , Kathleen A Gibbs  1   2 , Susan E Coffin  1   2
Affiliations

Healthcare-Associated Gastroenteritis: Outbreak Report and Systematic Review of the Literature

Nathan L'Etoile et al. J Pediatric Infect Dis Soc. .

Abstract

Healthcare-associated gastroenteritis continues to be associated with significant pediatric morbidity and mortality despite the introduction of rotavirus vaccines. Infection prevention (IP) measures are critical in mitigating outbreaks. We describe an outbreak of norovirus and effective IP strategies utilized and calculated the costs associated with the outbreak. To demonstrate the burden of these events, we conducted a systematic review of pediatric healthcare-associated gastroenteritis outbreaks since 1973 to describe changing epidemiologic trends. Twenty-four publications describing 27 outbreaks were included in the final analysis with 293 healthcare-associated cases. Rotavirus (14) and norovirus (7) outbreaks were most commonly described. Limitations include the retrospective nature of included reports, nonuniform data ascertainment and reporting among publications. Norovirus has replaced rotavirus as the most common etiology of healthcare-associated gastroenteritis outbreaks in North America, Europe, and Australia and New Zealand, since the introduction of rotavirus vaccines.

Keywords: epidemiology; healthcare-associated infections; norovirus; outbreaks; rotavirus.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Sharma R, Hudak ML, Premachandra BR, et al.Clinical manifestations of rotavirus infection in the neonatal intensive care unit. Pediatr Infect Dis J. 2002;21:1099–1105. https://doi.org/10.1097/00006454-200212000-00003 - DOI - PubMed
    1. Aliabadi N, Antoni S, Mwenda JM, et al.Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008–16: findings from the Global Rotavirus Surveillance Network. Lancet Global Health. 2019;7:e893–e903. https://doi.org/10.1016/s2214-109x(19)30207-4 - DOI - PMC - PubMed
    1. Chhabra P, Payne DC, Szilagyi PG, et al.Etiology of viral gastroenteritis in children <5 years of age in the United States, 2008–2009. J Infect Dis. 2013;208:790–800. https://doi.org/10.1093/infdis/jit254 - DOI - PubMed
    1. Shah MP, Hall AJ.. Norovirus illnesses in children and adolescents. Infect Dis Clin North Am. 2018;32:103–118. https://doi.org/10.1016/j.idc.2017.11.004 - DOI - PMC - PubMed
    1. Ogilvie I, Khoury H, Goetghebeur MM, El Khoury AC, Giaquinto C.. Burden of community-acquired and nosocomial rotavirus gastroenteritis in the pediatric population of Western Europe: a scoping review. BMC Infect Dis. 2012;12:62. https://doi.org/10.1186/1471-2334-12-62 - DOI - PMC - PubMed

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