Immune and non-immune congenital heart block: a tale of two very different entities

Susan P Etheridge^{1

2}, Janette F Strasburger³

Affiliations

¹ Division of Cardiology, Department of Pediatrics, Children's St. Lukes Hospital, Boise, ID 83712, USA.
² Stanford Lucile Packard Children's, Palo Alto, CA 94304, USA.
³ Professor of Pediatrics and Biomedical Engineering, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, WI, USA.

Editorial

Susan P Etheridge et al. Europace. 2025.

. 2025 Mar 5;27(3):euaf041.

doi: 10.1093/europace/euaf041.

Susan P Etheridge^{1

2}, Janette F Strasburger³

¹ Division of Cardiology, Department of Pediatrics, Children's St. Lukes Hospital, Boise, ID 83712, USA.
² Stanford Lucile Packard Children's, Palo Alto, CA 94304, USA.
³ Professor of Pediatrics and Biomedical Engineering, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, WI, USA.

No abstract available

Comment on

Late outcomes of congenital and childhood non-immune, isolated atrioventricular block: a French nationwide retrospective cohort study.
Mycinski F, Waldmann V, Kyndt F, Guyomarch B, Maltret A, Wilkin M, Ovaert C, Vaksmann G, Thambo JB, Sellal JM, Padovani P, Lwin N, Prigent S, Werner O, Barc J, Schott JJ, Bonnet D, Probst V, Baruteau AE; Congenital AVB study group. Mycinski F, et al. Europace. 2025 Mar 5;27(3):euaf040. doi: 10.1093/europace/euaf040. Europace. 2025. PMID: 40067976 Free PMC article.

1. Chubb H, Mah D, Dubin AM, Moore J. Conduction system pacing in pediatric and congenital heart disease. Front Physiol 2023;14:1154629. - PMC - PubMed
1. Paul T, Krause U, Sanatani S, Etheridge SP. Advancing the science of management of arrhythmic disease in children and adult congenital heart disease patients within the last 25 years. Europace 2023;25:euad155. - PMC - PubMed
1. Mycinki F, Waldmann V, Guyomarch B, Maltret A, Ovaert C et al. Late outcomes of congenital and childhood non-immune, isolated atrioventricular block: a French nationwide retrospective cohort study. Europace 2025. - PMC - PubMed
1. Baruteau AE, Fouchard S, Behaghel A, Mabo P, Villain E, Thambo JB et al. Characteristics and long-term outcome of non-immune isolated atrioventricular block diagnosed in utero or early childhood: a multicentre study. Eur Heart J 2012;33:622–9. - PubMed
1. Ambrosi A, Sonesson SE, Wahren-Herlenius M. Molecular mechanisms of congenital heart block. Exp Cell Res 2014;325:2–9. - PubMed