The use of combination advanced therapies in psoriatic arthritis: results from a UK multi-centre audit

Hannah Jethwa^{1

2}, Tania Gudu², Laura C Coates³, Philip S Helliwell⁴, William Tillett^{5

6}, Abdalla Abuelmagd⁵, Rajinder S Andev³, Madiha Ashraf³, Tanya Baqai⁷, Ernest Choy⁸, Dhivya Das⁸, Nicola Gullick^{9

10}, Catherine Heighton¹¹, Alison Kinder¹¹, Ramasharan Laxminarayan¹², Gayatri Mittal¹³, Penelope Morris¹⁴, Sandeep Mukherjee¹⁵, Anupama Nandagudi¹⁶, Satyapal Rangaraj¹⁷, Poonam Sharma¹⁸, Hoda Temple¹⁴, Beverly Traub¹², Vishal Paisal¹⁷, Ryan Hum¹⁹, Arani Vivekanantham³, Robert Wilson⁶, Deepak Jadon^{1

2}

Affiliations

¹ Department of Medicine, University of Cambridge, Cambridge, UK.
² Rheumatology Department, Cambridge University Hospitals NHSFT, Cambridge, UK.
³ Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, UK.
⁴ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Bradford Teaching Hospitals NHS Trust, Bradford, UK.
⁵ Rheumatology Department, Royal National Hospital for Rheumatic Diseases NHS Foundation Trust, Bath, UK.
⁶ Department of Life Sciences, University of Bath, Bath, UK.
⁷ Rheumatology Department, Luton and Dunstable Hospital NHS Foundation Trust, Luton, UK.
⁸ Cardiff Regional Experimental Arthritis Treatment and Evaluation Centre, Cardiff, UK.
⁹ Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
¹⁰ University of Warwick Medical School, Coventry, UK.
¹¹ Rheumatology Department, University Hospitals of Leicester NHS Trust, Leicester, UK.
¹² Rheumatology Department, University Hospitals of Derby and Burton NHS Foundation Trust, Burton on Trent, UK.
¹³ Rheumatology Department, Royal National Orthopaedic Hospital NHS Trust, London, UK.
¹⁴ Rheumatology Department, Countess of Chester Hospital NHS Foundation Trust, Chester, UK.
¹⁵ Rheumatology Department, The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, UK.
¹⁶ Rheumatology Department, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.
¹⁷ Rheumatology Department, Nottingham University Hospital NHS Trust, Nottingham, UK.
¹⁸ Rheumatology Department, North West Anglia NHS Foundation Trust, West Anglia, UK.
¹⁹ Rheumatology Department, Manchester University NHS Trust, Manchester, UK.

PMID: 40037587
PMCID: PMC12048059
DOI: 10.1093/rheumatology/keaf037

The use of combination advanced therapies in psoriatic arthritis: results from a UK multi-centre audit

Hannah Jethwa et al. Rheumatology (Oxford). 2025.

. 2025 May 1;64(5):3173-3176.

doi: 10.1093/rheumatology/keaf037.

Authors

Affiliations

¹ Department of Medicine, University of Cambridge, Cambridge, UK.
² Rheumatology Department, Cambridge University Hospitals NHSFT, Cambridge, UK.
³ Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, UK.
⁴ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Bradford Teaching Hospitals NHS Trust, Bradford, UK.
⁵ Rheumatology Department, Royal National Hospital for Rheumatic Diseases NHS Foundation Trust, Bath, UK.
⁶ Department of Life Sciences, University of Bath, Bath, UK.
⁷ Rheumatology Department, Luton and Dunstable Hospital NHS Foundation Trust, Luton, UK.
⁸ Cardiff Regional Experimental Arthritis Treatment and Evaluation Centre, Cardiff, UK.
⁹ Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
¹⁰ University of Warwick Medical School, Coventry, UK.
¹¹ Rheumatology Department, University Hospitals of Leicester NHS Trust, Leicester, UK.
¹² Rheumatology Department, University Hospitals of Derby and Burton NHS Foundation Trust, Burton on Trent, UK.
¹³ Rheumatology Department, Royal National Orthopaedic Hospital NHS Trust, London, UK.
¹⁴ Rheumatology Department, Countess of Chester Hospital NHS Foundation Trust, Chester, UK.
¹⁵ Rheumatology Department, The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, UK.
¹⁶ Rheumatology Department, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.
¹⁷ Rheumatology Department, Nottingham University Hospital NHS Trust, Nottingham, UK.
¹⁸ Rheumatology Department, North West Anglia NHS Foundation Trust, West Anglia, UK.
¹⁹ Rheumatology Department, Manchester University NHS Trust, Manchester, UK.

PMID: 40037587
PMCID: PMC12048059
DOI: 10.1093/rheumatology/keaf037

No abstract available

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References

1. Najm A, Goodyear CS, McInnes IB, Siebert S. Phenotypic heterogeneity in psoriatic arthritis: towards tissue pathology-based therapy. Nat Rev Rheumatol 2023;19:153–65. - PubMed
1. Mease PJ, Genovese MC, Weinblatt ME et al. Phase II study of ABT-122, a tumor necrosis factor- and interleukin-17A-targeted dual variable domain immunoglobulin, in patients with psoriatic arthritis with an inadequate response to methotrexate. Arthritis Rheumatol (Hoboken, NJ) 2018;70:1778–89. - PMC - PubMed
1. Haberman RH, , CastilloR, , Scher JU. Induction of remission in biologic-naive, severe psoriasis and PsA with dual anti-cytokine combination. Rheumatology (Oxford, England) 2021;60:e225–6. - PMC - PubMed
1. Abignano G, Fadl N, Merashli M et al. A comparison of apremilast monotherapy and combination therapy for psoriatic arthritis in a real-life setting: data from the Leeds Combined Psoriatic Service. J Ame Acad Dermatol 2019;80:1796–8. - PubMed
1. Shurey M, Yip A, Ziouzina O, Chan J, Dutz JP. Combination therapy with tofacitinib and IL-12/23, IL-23, or IL-17A inhibition for the treatment of refractory psoriatic arthritis: a case series. JCR J Clin Rheumatol 2022;28:e626–e8. - PubMed

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The use of combination advanced therapies in psoriatic arthritis: results from a UK multi-centre audit

Affiliations

The use of combination advanced therapies in psoriatic arthritis: results from a UK multi-centre audit

Authors

Affiliations

References

LinkOut - more resources

Full Text Sources