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. 2025 Mar 5;15(1):7651.
doi: 10.1038/s41598-025-91069-x.

Cannulated intravaginal injection technique (CIVIT) A Novel Vaginal Injection Technique

Ozgur Leylek  1 , Berna Haliloglu Peker  2 , Ergul Demircivi  3 , Hakan Peker  4
Affiliations

Cannulated intravaginal injection technique (CIVIT) A Novel Vaginal Injection Technique

Ozgur Leylek et al. Sci Rep. .

Abstract

Non-surgical procedures such as fillers, PRP and derivatives, energy-based devices and adipose derivate mesenchymal stem cell treatments are begun to be used in women genital area for both functional and aesthetic purposes. After theproduction of injectable HA for genital use, patients were able to benefit more effectively from these applications and its use in the vagina became more common. In our study, we aimed to demonstrate a new intravaginal injection technique, Cannulated Intravaginal Injection Technique (CIVIT) that we can perform vaginal injection more homogenously and less traumatic and more effectively to the entire vaginal mucosa. Retrospectively, the data of 44 patients who underwent intravaginal injection of HA manufactured for genital use at a private Female Health Clinic were analyzed. Of the 44 patients, 21 were injected using the random needling technique, and 22 were injected using CIVIT. All patients had symptoms of genitourinary syndrome (GUS), a vaginal health index below 15, and were compared based on the Female Sexual Function Index (FSFI) and visual analogue scale (VAS) for GUS before and after the procedures. It was observed that all post-injection values, except for FSFI arousal (p = 0.539), were statistically significantly higher in the CIVIT group (P = 0.001). Post injection dryness, dyspareunia and discomfort values decreased significantly in the CIVIT group compared to the Random Needling group. Our new technique, CIVIT, and random injection, which is a frequently used technique, are two effective techniques for vaginal rejuvenation. However, CIVIT is significantly more effective than the random technique in improving genitourinary symptoms, vaginal health index and sexual function.

Keywords: Female sexual function; Genitourinary syndrome; Intravaginal injection; Vaginal health.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethical approval: This study was conducted as a sub-study of the research project approved by the ethics committee (Maltepe University Medical Ethics Committee) with the number 2021/900/89 as a result of retrospective evaluation of the data. This study performed with ‘relevant guidelines or institution name or ethical committee guidelines’. Informed consent was obtained from every participate.

Figures

Fig. 1
Fig. 1
Injection points of cannulated intravaginal injection technique.
Fig. 2
Fig. 2
Entry points of cannulated intravaginal injection technique.
See this image and copyright information in PMC

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