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Published Erratum
. 2025 Mar 4;15(1):7615.
doi: 10.1038/s41598-025-91682-w.

Author Correction: Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

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Published Erratum

Author Correction: Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Shan-Shan Zhang et al. Sci Rep. .
No abstract available

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Figures

Fig. 5
Fig. 5
RXFP2 antagonists block INSL3-stimulated steroidogenesis and corticosteroid secretion in human adrenal cortex cells H295R stably expressing RXFP2. (a) Dose–response curves of RXFP2 mAb treatment in H295R cells stably expressing rat RXFP2 stimulated with 3.5 nM rat INSL3 (EC80) on CYP11B1 (steroid 11β-hydroxylase enzyme) and CYP11B2 (aldosterone synthase) mRNA expression levels (qPCR, relative to GAPDH control). IgG n = 6; all others n = 2. (b) The supernatants of cells stimulated with INSL3 and treated with the RXFP2 mAbs 1F2, 4G6, and 2D4 were assayed for cortisol (n = 2) and 2D4 was also evaluated for aldosterone (n = 2) concentration (ELISA). (c) Dose–response curve of RXFP2 small molecule antagonist GSK618069 in H295R cells stably expressing rat RXFP2 and stimulated with 3.5 nM rat INSL3 (EC80) on CYP11B2 (aldosterone synthase) mRNA expression levels (qPCR, relative to GAPDH). (d) Proposed hypothesis for a role of RXFP2 in causing hypertension through adrenal steroidogenesis and secretion. Graphic was created using BioRender.com. Small molecule compound (SMC).

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