Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Aug;55(8):659-670.
doi: 10.1111/cea.70014. Epub 2025 Mar 4.

Hereditary Angioedema (HAE) in China: Advancing Awareness, Access, Advocacy and Alliances From the Greater Bay Area to the Global HAE Community

Philip H Li  1   2 , Jin-Xian Huang  2 , Can-Tian Wang  2 , Jane C Y Wong  1   2 , Hao Chen  3 , Bao Chai  4   5 , Liang Chen  5 , He Lai  6 , Shuo Li  5 , Yan-Hua Liang  7 , Yun-Sheng Liang  8 , Ning Liu  2 , Bing Lu  5 , Bao-Qing Sun  9 , Qin-Tai Yang  10   11 , Fei Ye  12 , Jiang-Lin Zhang  13 , Shu-Chen Zhang  14 , Zuo-Tao Zhao  15 , Min Zhou  10 , Xian-Biao Zou  16 , Guang-Hui Liu  3 , Kai Guan  17
Affiliations
Review

Hereditary Angioedema (HAE) in China: Advancing Awareness, Access, Advocacy and Alliances From the Greater Bay Area to the Global HAE Community

Philip H Li et al. Clin Exp Allergy. 2025 Aug.

Abstract

The article offers an overview of the progress in managing Hereditary Angioedema (HAE) in China, with a specific focus on the Greater Bay Area (GBA). Through the '4As' framework-Awareness, Access, Advocacy and Alliance-the article explores the challenges and advancements in HAE care. In terms of collaborative initiatives such as the HAE-ASIA (Angioedema Screening In Asia) collaboration and the GBA HAE Alliance "Hub-and-Spoke model" aim to bridge the gap between East and West, providing optimal patient care and advancing HAE management. By bridging the gap between East and West, the GBA aims to deliver optimal patient care and advance HAE management. Moving forward, it will be essential to persist in nurturing national and international collaborations, not only within China but also extending beyond its borders. These partnerships encourage the exchange of knowledge, research, and best practices, all of which are critical in propelling forward the care of HAE. By uniting as a worldwide community, we can significantly advance efforts to improve the quality of life for those affected by HAE across the globe.

Keywords: China; Greater Bay Area; access; advocacy; alliance; angioedema; awareness; hereditary.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Illustrative map of the Greater Bay Area (Guangdong‐Hong Kong‐Macau) and the location of ACARE centres in China. Figures made from mapchart.net and paintmaps.com.
FIGURE 2
FIGURE 2
Bibliometric analysis of all HAE‐related publications from China and comparator country, indexed on MEDLINE between 1987 and 2024.
FIGURE 3
FIGURE 3
Example of a HAE family demonstrating increased diagnostic yield after combining DBS to an outreach cascade family screening programme.
FIGURE 4
FIGURE 4
International collaborations of HAE research with China between the periods (A) 2011–2017 and (B) 2018–2024. Countries in darker shades of colour represent higher number of HAE‐related publications. Lines indicate ≥ 5 HAE‐related publications published together between China and those countries within time‐period.
See this image and copyright information in PMC

Similar articles

  • Disease control and disease activity in hereditary angioedema: two sides of the same coin?
    Heibati B, Borle J, Ritchie B, Adatia A. Heibati B, et al. Front Immunol. 2025 Jul 22;16:1631448. doi: 10.3389/fimmu.2025.1631448. eCollection 2025. Front Immunol. 2025. PMID: 40766317 Free PMC article.
  • Unmet needs in hereditary angioedema: an international survey of physicians.
    Buttgereit T, Aulenbacher F, Adatia A, Ayala CV, Al-Nesf MA, Altrichter S, Abuzakouk M, Al-Ahmad M, Ali RM, Berardi A, Boccon-Gibod I, Bouillet L, Brussino L, Barešić M, Busse PJ, Betschel SD, Chong-Neto H, Llosa OC, Craig TJ, Dorr AD, Junior SDD, Fomina D, Farkas H, Fok JS, Grumach AS, Greve J, Guilarte M, Gonçalo M, Grivcheva-Panovska V, Hide M, Hakl R, Jindal A, Katelaris CH, Kamaleswaran S, Kinaciyan T, Latysheva E, Sousa JIL, Bellfill RL, Mobayed H, Metz M, Nasr I, Mitrevska NT, Nicola S, Parisi CAS, Porebski G, Peter J, Ferriani MPL, Filho NR, Şekerel BE, Serpa FS, Stobiecki M, Trainotti S, Valerieva A, Wongsa C, Wong JCY, Yucel E, Li Y, Nenci C, Maurer M, Magerl M, Li PH. Buttgereit T, et al. Orphanet J Rare Dis. 2025 Jul 28;20(1):383. doi: 10.1186/s13023-025-03739-8. Orphanet J Rare Dis. 2025. PMID: 40722187 Free PMC article.
  • Interventions for the long-term prevention of hereditary angioedema attacks.
    Beard N, Frese M, Smertina E, Mere P, Katelaris C, Mills K. Beard N, et al. Cochrane Database Syst Rev. 2022 Nov 3;11(11):CD013403. doi: 10.1002/14651858.CD013403.pub2. Cochrane Database Syst Rev. 2022. PMID: 36326435 Free PMC article.
  • Interventions to improve safe and effective medicines use by consumers: an overview of systematic reviews.
    Ryan R, Santesso N, Lowe D, Hill S, Grimshaw J, Prictor M, Kaufman C, Cowie G, Taylor M. Ryan R, et al. Cochrane Database Syst Rev. 2014 Apr 29;2014(4):CD007768. doi: 10.1002/14651858.CD007768.pub3. Cochrane Database Syst Rev. 2014. PMID: 24777444 Free PMC article.
  • Management of urinary stones by experts in stone disease (ESD 2025).
    Papatsoris A, Geavlete B, Radavoi GD, Alameedee M, Almusafer M, Ather MH, Budia A, Cumpanas AA, Kiremi MC, Dellis A, Elhowairis M, Galán-Llopis JA, Geavlete P, Guimerà Garcia J, Isern B, Jinga V, Lopez JM, Mainez JA, Mitsogiannis I, Mora Christian J, Moussa M, Multescu R, Oguz Acar Y, Petkova K, Piñero A, Popov E, Ramos Cebrian M, Rascu S, Siener R, Sountoulides P, Stamatelou K, Syed J, Trinchieri A. Papatsoris A, et al. Arch Ital Urol Androl. 2025 Jun 30;97(2):14085. doi: 10.4081/aiua.2025.14085. Epub 2025 Jun 30. Arch Ital Urol Androl. 2025. PMID: 40583613 Review.
See all similar articles

Cited by

References

    1. Busse P. J. and Christiansen S. C., “Hereditary Angioedema,” New England Journal of Medicine 382 (2020): 1136–1148. - PubMed
    1. Maurer M., Magerl M., Betschel S., et al., “The International WAO/EAACI Guideline for the Management of Hereditary Angioedema‐The 2021 Revision and Update,” Allergy 77 (2022): 1961–1990. - PubMed
    1. Zuberbier T., Abdul Latiff A. H., Abuzakouk M., et al., “The International EAACI/GA(2)LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis, and Management of Urticaria,” Allergy 77 (2022): 734–766. - PubMed
    1. Reshef A., Buttgereit T., Betschel S. D., et al., “Definition, Acronyms, Nomenclature, and Classification of Angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE Consensus,” Journal of Allergy and Clinical Immunology 154 (2024): 398–411. - PubMed
    1. Bock S. C., Skriver K., Nielsen E., et al., “Human C1 Inhibitor: Primary Structure, cDNA Cloning, and Chromosomal Localization,” Biochemistry 25 (1986): 4292–4301. - PubMed

MeSH terms

LinkOut - more resources