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Review
. 2025 Aug;55(8):659-670.
doi: 10.1111/cea.70014. Epub 2025 Mar 4.

Hereditary Angioedema (HAE) in China: Advancing Awareness, Access, Advocacy and Alliances From the Greater Bay Area to the Global HAE Community

Philip H Li  1   2 , Jin-Xian Huang  2 , Can-Tian Wang  2 , Jane C Y Wong  1   2 , Hao Chen  3 , Bao Chai  4   5 , Liang Chen  5 , He Lai  6 , Shuo Li  5 , Yan-Hua Liang  7 , Yun-Sheng Liang  8 , Ning Liu  2 , Bing Lu  5 , Bao-Qing Sun  9 , Qin-Tai Yang  10   11 , Fei Ye  12 , Jiang-Lin Zhang  13 , Shu-Chen Zhang  14 , Zuo-Tao Zhao  15 , Min Zhou  10 , Xian-Biao Zou  16 , Guang-Hui Liu  3 , Kai Guan  17
Affiliations
Review

Hereditary Angioedema (HAE) in China: Advancing Awareness, Access, Advocacy and Alliances From the Greater Bay Area to the Global HAE Community

Philip H Li et al. Clin Exp Allergy. 2025 Aug.

Abstract

The article offers an overview of the progress in managing Hereditary Angioedema (HAE) in China, with a specific focus on the Greater Bay Area (GBA). Through the '4As' framework-Awareness, Access, Advocacy and Alliance-the article explores the challenges and advancements in HAE care. In terms of collaborative initiatives such as the HAE-ASIA (Angioedema Screening In Asia) collaboration and the GBA HAE Alliance "Hub-and-Spoke model" aim to bridge the gap between East and West, providing optimal patient care and advancing HAE management. By bridging the gap between East and West, the GBA aims to deliver optimal patient care and advance HAE management. Moving forward, it will be essential to persist in nurturing national and international collaborations, not only within China but also extending beyond its borders. These partnerships encourage the exchange of knowledge, research, and best practices, all of which are critical in propelling forward the care of HAE. By uniting as a worldwide community, we can significantly advance efforts to improve the quality of life for those affected by HAE across the globe.

Keywords: China; Greater Bay Area; access; advocacy; alliance; angioedema; awareness; hereditary.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Illustrative map of the Greater Bay Area (Guangdong‐Hong Kong‐Macau) and the location of ACARE centres in China. Figures made from mapchart.net and paintmaps.com.
FIGURE 2
FIGURE 2
Bibliometric analysis of all HAE‐related publications from China and comparator country, indexed on MEDLINE between 1987 and 2024.
FIGURE 3
FIGURE 3
Example of a HAE family demonstrating increased diagnostic yield after combining DBS to an outreach cascade family screening programme.
FIGURE 4
FIGURE 4
International collaborations of HAE research with China between the periods (A) 2011–2017 and (B) 2018–2024. Countries in darker shades of colour represent higher number of HAE‐related publications. Lines indicate ≥ 5 HAE‐related publications published together between China and those countries within time‐period.
See this image and copyright information in PMC

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