A Method for Minimally-Invasive Injection of Wireless Microdevices into Brain Tissue

Abstract

As the field advances with the introduction of a new generation of electrodes, the demand for refined injection methodologies becomes evident. These electrodes, frequently termed microdevices, are intricately microfabricated and require precise insertion into neural tissue. Despite the existence of conventional injection methods, there is a pressing need to formulate strategies aimed at minimizing the damage associated with the deployment of microdevices of varied sizes and configurations. In recognition of this need, the introduced technique can be applied for damage mitigation when injecting microdevices into brain tissue. We introduce a novel injection aid and describe an injection technique that results in reduced tissue damage. The damage of injecting into agarose and the brain, with and without the aid of a tool that creates microvibrations is evaluated. Cryosectioning data is presented to assess the damage caused by the injection, which was found to be 7.4% less when using microvibrations.