Engineered MXene Biomaterials for Regenerative Medicine

Abstract

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant to fields such as energy storage, environmental science, and biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications in tissue regeneration is still in its early stages, with a notable absence of comprehensive reviews. This review begins with a detailed description of the intrinsic properties of MXene, followed by a discussion of the various nanostructures that MXene can form, spanning from 0 to 3 dimensions. The focus then shifts to the applications of MXene-based biomaterials in tissue engineering, particularly in immunomodulation, wound healing, bone regeneration, and nerve regeneration. MXene's physicochemical properties, including conductivity, photothermal characteristics, and antibacterial properties, facilitate interactions with different cell types, influencing biological processes. These interactions highlight its potential in modulating cellular functions essential for tissue regeneration. Although the research on MXene in tissue regeneration is still developing, its versatile structural and physicochemical attributes suggest its potential role in advancing regenerative medicine.

Keywords: MXene; biomedicine; bone tissue regeneration; cell regulation; immunoregulation; nanostructure; neural tissue regeneration; tissue regeneration; wound healing.