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Review
. 2025 Feb 18:16:1489277.
doi: 10.3389/fimmu.2025.1489277. eCollection 2025.

Role of skin-homing t-cells in recurrent episodes of atopic dermatitis: a review

Huimin Guo #  1 , Huimin Yuan #  1   2 , Yanru Yu  1 , Jingwei Sun  1 , Yan Sun  1 , Yang Tang  1 , Fengjie Zheng  1
Affiliations
Review

Role of skin-homing t-cells in recurrent episodes of atopic dermatitis: a review

Huimin Guo et al. Front Immunol. .

Abstract

Atopic dermatitis (AD) is a chronic relapsing disease with complex pathogenesis. Among them, inflammation is one of the primary pathogenesis of AD. AD is characterized by infiltration of lymphocytes into the skin's dermis, and the skin homing of lymphocytes plays an essential role in the recurrence of AD. Currently, there is more and more evidence to support this view. This article reviews the relevant role of T lymphocyte skin-homing-related molecules in the recurrence of AD to provide a reference for the cure of AD.

Keywords: T lymphocytes; atopic dermatitis; pathogenesis; recurrence; skin-homing.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The role of TEM homing to the skin in AD recurrence. TEMs in blood vessels achieve adhesion and rolling of lymphocytes on high endothelial venules through the interaction of CLA, LFA-1, and VLA-4 molecules on their surface, as well as their ligands E-selectin family, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 on the surface of vascular endothelial cells. Subsequently, CCR4 and CCR10 expressed on TEMs interact with CCL17 and CCL27 produced by keratinocytes. TEMs eventually stay and cross endothelial cells to achieve skin homing and produce cytokines, which further disrupt the skin barrier, leading to the recurrence of AD. In addtion, TRMs also participate in the immune response and produce cytokines during AD recurrence. In non-lesional skin, there is also a slight inflammatory response.
See this image and copyright information in PMC

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