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. 2025 Feb 18:18:1534569.
doi: 10.3389/fnmol.2025.1534569. eCollection 2025.

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

Jacob Peedicayil  1 , Samuel Santhosh  1
Affiliations

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

Jacob Peedicayil et al. Front Mol Neurosci. .
No abstract available

Keywords: epigenetic; histone; monoamine; novel; psychiatry.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) Schematic showing monoaminylation at the glutamine 5 position on the tail of histone H3 (H3Q5) a possible new epigenetic mechanism in psychiatric disorders. The parts of the figure shown in yellow are the histones around which the DNA strand shown in red is coiled. TGM2, Transglutamine 2; Q, Glutamine (at position 5 of the tail of histone H3). (B) Schematic of a portion of the tail of histone H3 showing the presence of glutamine (Q) at position 5 (shown in red) of the histone tail. Abbreviations: aa, amino acids. A, alanine; R, arginine; S, serine; T, threonine; K, lysine; Q, glutamine.
See this image and copyright information in PMC

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