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. 1985 Apr;27(4):660-2.
doi: 10.1128/AAC.27.4.660.

Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits

F Dromer, A Contrepois, N Brion, C Klein, C Carbon

Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits

F Dromer et al. Antimicrob Agents Chemother. 1985 Apr.

Abstract

The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in alkaline urine (FE = 492 +/- 258%). Renal excretion of cefsulodin alone was not affected by the urinary pH (FE = ca. 100%). In acidic urine, probenecid significantly reduced tubular secretion of cefsulodin (FE = 74 +/- 8%). An inverse pattern was observed in alkaline urine (FE = 122 +/- 18%).

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