Pocket guide: biologics in upper and lower airways in adults

W J Fokkens¹, V Backer², V J Lund³, P J Barnes⁴, M Bernal-Sprekelsen⁵, L Bjermer⁶, E de Corso⁷, D M Conti⁸, M E Cornet⁹, Z Diamant¹⁰, R Djukanovic¹¹, M Gaga¹², P Gevaert¹³, J K Han¹⁴, C Hopkins¹⁵, G Joos¹⁶, B N Landis¹⁷, S Lau¹⁸, S E Lee¹⁹, J Mullol²⁰, A T Peters²¹, G K Scadding²², S Schneider²³, B Senior²⁴, I D Pavord²⁵, S Quirce²⁶, D Ryan²⁷, M E Wechsler²⁸, P W Hellings²⁹

Affiliations

¹ Amsterdam UMC, University of Amsterdam, Department of Otorhinolarynogology, Amsterdam, the Netherlands.
² Department of Otorhinolaryngology, Head and Neck surgery and Audiology, Rigshospitalet, Copenhagen University Hospitalet, Copenhagen, Denmark.
³ University College London, London, United Kingdom; Royal National Throat Nose and Ear Hospital, UCLH, London, United Kingdom.
⁴ Royal National Heart and Lung Institute, Imperial College London, London, United Kingdom.
⁵ Hospital Clinic, Barcelona, University of Barcelona, Spain.
⁶ Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden.
⁷ UOC Otorinolaringoiatria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
⁸ The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members.
⁹ Department of Otorhinolaryngology, Alrijne Hospital, Leiden, the Netherlands.
¹⁰ Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, the Netherlands.
¹¹ School of Clinical and Experimental Sciences, Medical Faculty, University of Southampton and NIHR Southampton Biomedical Research Centre, Southampton, United Kingdom.
¹² 1st Respiratory Medicine Department, Hygeia Hospital, Marousi, Greece.
¹³ Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium.
¹⁴ Department of Otolaryngology and Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA, USA.
¹⁵ King's College London, London, United Kingdom.
¹⁶ Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences at Ghent University, Belgium.
¹⁷ Unite de Rhinologie-Olfactologie, Service d'Oto-Rhino-Laryngologie et de Chirurgie cervico-faciale, Hopitaux Universitaires de Geneve, Geneve, Switzerland.
¹⁸ CharitÃ© Universitatsmedizin Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Berlin, Germany.
¹⁹ Division of Otolaryngology - Head and Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
²⁰ Rhinology Unit and Smell Clinic, ENT Department, Hospital Clinic Barcelona, IDIBAPS, Universitat de Barcelona, CIBERES. Barcelona, Catalonia, Spain.
²¹ Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
²² Department of Allergy and Rhinology, Royal National ENT Hospital,London, United Kingdom, Division of Immunity and Infection, University College, London, United Kingdom.
²³ Department of Otorhinolaryngology - Head and Neck Surgery, Medical University of Vienna, Austria.
²⁴ Harold C Pillsbury, III Distinguished Professor of Otolaryngology, Chief, Division of Rhinology, Allergy, and Endoscopic Skull Base Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
²⁵ Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
²⁶ Department of Allergy, La Paz University Hospital, IdiPAZ, Madrid, Spain.
²⁷ AUKCAR, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
²⁸ Department of Medicine, National Jewish Health, Denver, CO, USA.
²⁹ The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members; Department of Otorhinolaryngology - Head and Neck Surgery, University Hospitals, Leuven, Belgium; Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium.

PMID: 40042485
DOI: 10.4193/Rhin24.510

Practice Guideline

Pocket guide: biologics in upper and lower airways in adults

W J Fokkens et al. Rhinology. 2025.

. 2025 Apr 1;63(2):242-244.

doi: 10.4193/Rhin24.510.

Authors

Affiliations

¹ Amsterdam UMC, University of Amsterdam, Department of Otorhinolarynogology, Amsterdam, the Netherlands.
² Department of Otorhinolaryngology, Head and Neck surgery and Audiology, Rigshospitalet, Copenhagen University Hospitalet, Copenhagen, Denmark.
³ University College London, London, United Kingdom; Royal National Throat Nose and Ear Hospital, UCLH, London, United Kingdom.
⁴ Royal National Heart and Lung Institute, Imperial College London, London, United Kingdom.
⁵ Hospital Clinic, Barcelona, University of Barcelona, Spain.
⁶ Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden.
⁷ UOC Otorinolaringoiatria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
⁸ The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members.
⁹ Department of Otorhinolaryngology, Alrijne Hospital, Leiden, the Netherlands.
¹⁰ Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, the Netherlands.
¹¹ School of Clinical and Experimental Sciences, Medical Faculty, University of Southampton and NIHR Southampton Biomedical Research Centre, Southampton, United Kingdom.
¹² 1st Respiratory Medicine Department, Hygeia Hospital, Marousi, Greece.
¹³ Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium.
¹⁴ Department of Otolaryngology and Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA, USA.
¹⁵ King's College London, London, United Kingdom.
¹⁶ Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences at Ghent University, Belgium.
¹⁷ Unite de Rhinologie-Olfactologie, Service d'Oto-Rhino-Laryngologie et de Chirurgie cervico-faciale, Hopitaux Universitaires de Geneve, Geneve, Switzerland.
¹⁸ CharitÃ© Universitatsmedizin Berlin, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Berlin, Germany.
¹⁹ Division of Otolaryngology - Head and Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
²⁰ Rhinology Unit and Smell Clinic, ENT Department, Hospital Clinic Barcelona, IDIBAPS, Universitat de Barcelona, CIBERES. Barcelona, Catalonia, Spain.
²¹ Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
²² Department of Allergy and Rhinology, Royal National ENT Hospital,London, United Kingdom, Division of Immunity and Infection, University College, London, United Kingdom.
²³ Department of Otorhinolaryngology - Head and Neck Surgery, Medical University of Vienna, Austria.
²⁴ Harold C Pillsbury, III Distinguished Professor of Otolaryngology, Chief, Division of Rhinology, Allergy, and Endoscopic Skull Base Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
²⁵ Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
²⁶ Department of Allergy, La Paz University Hospital, IdiPAZ, Madrid, Spain.
²⁷ AUKCAR, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
²⁸ Department of Medicine, National Jewish Health, Denver, CO, USA.
²⁹ The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members; Department of Otorhinolaryngology - Head and Neck Surgery, University Hospitals, Leuven, Belgium; Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium.

PMID: 40042485
DOI: 10.4193/Rhin24.510

Abstract

The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a game changer in the management of these diseases. Biologics are injectable medications targeting different molecules relevant in (type 2) inflammation in patients with severe (type 2) airway diseases, like asthma, eosinophilic chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis (CRS) and those who remain uncontrolled despite regular treatment. After the phase 3 trials, showing significant impact on symptoms, quality of life and interventions like surgery (for the upper airways) and exacerbations needing hospitalisation (for the lower airways), biologics are now used in daily practice in many parts of the world. This pocket guide is aimed at all specialists treating adult patients with severe airway disease.

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Pocket guide: biologics in upper and lower airways in adults

Affiliations

Pocket guide: biologics in upper and lower airways in adults

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical