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. 2025 Jun;211(6):1072-1075.
doi: 10.1164/rccm.202501-0093RL.

Camlipixant in Refractory Chronic Cough: A Phase 2a, Randomized Controlled Trial (RELIEF)

Jaclyn A Smith  1 , Alyn H Morice  2 , Surinder S Birring  3 , Sean M Parker  4 , Paul A Marsden  1 , John R Holcomb  5 , Mandel Sher  6 , Bruce M Prenner  7 , Gary Steven  8 , Kevin J Carroll  9 , Sylvain Lanouette  10 , Denis Garceau  10 , Laurent Harvey  10 , Catherine M Bonuccelli  11
Affiliations

Camlipixant in Refractory Chronic Cough: A Phase 2a, Randomized Controlled Trial (RELIEF)

Jaclyn A Smith et al. Am J Respir Crit Care Med. 2025 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Study design and (B–D) placebo-adjusted change from baseline in awake cough frequency. Forest plot of mean placebo-adjusted change in awake cough frequency for (B) the intention-to-treat (ITT) population and (C and D) prespecified subgroups at each dose level. Error bars represent 95% CI. P values (two-sided) are presented. Patients were treated BID for 4 days at each dose level. *P < 0.05. A mixed model for repeated measures was used to compare camlipixant with placebo for all cough frequency endpoints; data were analyzed on a natural log scale. Sensitivity analyses assessed the primary efficacy endpoint in the per-protocol and completers groups, through worst-case imputation, and in the ITT population. BID = twice daily; CI = confidence interval.
See this image and copyright information in PMC

References

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