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Editorial
. 2025 Mar;51(3):582-584.
doi: 10.1007/s00134-025-07828-x. Epub 2025 Mar 6.

Subphenotypes and phenotypes to resolve sepsis heterogeneity: hype or hope?

Andre C Kalil  1 , Pedro Povoa  2   3   4 , Marc Leone  5
Affiliations
Editorial

Subphenotypes and phenotypes to resolve sepsis heterogeneity: hype or hope?

Andre C Kalil et al. Intensive Care Med. 2025 Mar.
No abstract available

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Conflict of interest statement

Declarations. Conflicts of interest: Andre Kalil: no conflicts of interest to disclose. Pedro Povoa: honoraria for lectures and advisory board from Merck Sharp & Dohme, Gilead, BioCodex and Mundipharma. Marc Leone: served as speaker for Shionogi and Grifols, and advisor for Edwards Life Sciences, Previa, and Viatris.

References

    1. Kalil AC (2013) Deciphering the sepsis riddle: we can learn from Star Trek. Crit Care Med 41:2458–2460 - DOI - PubMed
    1. Kalil AC, Sweeney DA (2018) Should we manage all septic patients based on a single definition? An alternative approach. Crit Care Med 46:177–180 - DOI - PubMed
    1. Perner A, Gordon AC, De Backer D, Dimopoulos G, Russell JA, Lipman J, Jensen JU, Myburgh J, Singer M, Bellomo R, Walsh T (2016) Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Med 42:1958–1969 - DOI - PubMed
    1. Leone M, Lakbar I, Vincent JL (2023) Not available. Rev Epidemiol Sante Publique 71:102176 - DOI - PubMed
    1. Kalil AC, Johnson DW, Lisco SJ, Sun J (2017) Early goal-directed therapy for sepsis: a novel solution for discordant survival outcomes in clinical trials. Crit Care Med 45:607–614 - DOI - PubMed

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