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Case Reports
. 2025 May;44(5):1273-1277.
doi: 10.1007/s10096-025-05093-w. Epub 2025 Mar 6.

Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland

Abdessalam Cherkaoui  1 , Patrice Francois  2 , Nadia Gaia  2 , Gesuele Renzi  3 , Adrien Fischer  3 , Jacques Schrenzel  3   2
Affiliations
Case Reports

Extensively drug-resistant Haemophilus influenzae isolated in Geneva, Switzerland

Abdessalam Cherkaoui et al. Eur J Clin Microbiol Infect Dis. 2025 May.

Abstract

The emergence of multi-drug resistant (MDR) and even extensively drug-resistant (XDR) strains among H. influenzae was observed in some Asian countries. Herein, we reported the first XDR H. influenzae isolated in Geneva, Switzerland. This strain was isolated in a good-quality sputum sample from a 63 year-old male patient. There was no respiratory infection diagnosed at that time. The strain was non-typeable and pan-β-lactam resistant. According to whole genome sequencing analysis it belongs to sequence type 159 and the ST-107 clonal complex. It was classified into group III + regarding the amino acid substitutions identified in the transpeptidase domain of PBP3.

Keywords: Haemophilus influenzae; Ceftriaxone resistance; Extensively drug resistant; Penicillin-binding protein 3 amino acid substitutions.

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Conflict of interest statement

Declarations. Informed consent: In accordance with local ethical committee, routine clinical laboratories of our institution may use biological sample leftovers for method development after irreversible anonymization of data. Thus, non-informed consent is required. The official name of the ethics committee is “Commission cantonale d'éthique de la recherche (CCER)” https://www.hug-ge.ch/ethique All experimental protocols were approved by the ethics committee. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: This research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest or competing interests.

Figures

Fig. 1
Fig. 1
Phylogenetic tree and a pairwise SNP table
See this image and copyright information in PMC

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