Associations between Blood DNA Methylation and Histopathologic Features in Lupus Nephritis

Patrick Demkowicz¹, Ieva Kavaliauskaite², Sophia C Faulkner³, Candice Kent³, Melissa Shaw³, Deepika Kumar⁴, Joachim H Ix^{5

6}, F Perry Wilson^{3

7}, Dennis G Moledina^{3

7}, Mathieu F Bakhoum^{2

4

8}, Christine Y Bakhoum^{3

9}

Affiliations

¹ Yale University School of Medicine, New Haven, Connecticut.
² Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut.
³ Clinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
⁴ Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
⁵ Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California.
⁶ Nephrology Section, Medicine Service, Veterans Affairs San Diego Healthcare System, La Jolla, California.
⁷ Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
⁸ Yale Cancer Center, Yale University, New Haven, Connecticut.
⁹ Section of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.

Patrick Demkowicz et al. Kidney360. 2025.

. 2025 Mar 6;6(8):1404-1408.

doi: 10.34067/KID.0000000758.

¹ Yale University School of Medicine, New Haven, Connecticut.
² Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut.
³ Clinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
⁴ Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
⁵ Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California.
⁶ Nephrology Section, Medicine Service, Veterans Affairs San Diego Healthcare System, La Jolla, California.
⁷ Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
⁸ Yale Cancer Center, Yale University, New Haven, Connecticut.
⁹ Section of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.

No abstract available

Keywords: SLE; lupus nephritis.

Conflict of interest statement

Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/KN9/A938.

1. Mok CC, Teng YKO, Saxena R, Tanaka Y. Treatment of lupus nephritis: consensus, evidence and perspectives. Nat Rev Rheumatol. 2023;19(4):227–238. doi: 10.1038/s41584-023-00925-5 - DOI - PubMed
1. Ferreté-Bonastre AG, Cortés-Hernández J, Ballestar E. What can we learn from DNA methylation studies in lupus?. Clin Immunol. 2022;234:108920. doi: 10.1016/j.clim.2021.108920 - DOI - PubMed
1. Joseph S George NI Green-Knox B, et al. Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI. J Autoimmun. 2019;96:147–157. doi: 10.1016/j.jaut.2018.09.007 - DOI - PubMed
1. Ulff-Møller CJ Asmar F Liu Y, et al. Twin DNA methylation profiling reveals flare-dependent interferon signature and B cell promoter hypermethylation in systemic lupus erythematosus. Arthritis Rheumatol. 2018;70(6):878–890. doi: 10.1002/art.40422 - DOI - PubMed
1. Zhao M Liu S Luo S, et al. DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype. J Autoimmun. 2014;54:127–136. doi: 10.1016/j.jaut.2014.07.002 - DOI - PubMed