doi: 10.1016/0006-2952(85)90643-4.
5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylase
- PMID: 4004890
- DOI: 10.1016/0006-2952(85)90643-4
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5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylase
Biochem Pharmacol.
.
Abstract
5-Substituted-2,2'-anhydrouridines are a new class of competitive inhibitors of uridine phosphorylase. The most potent member of the series is 2,2'-anhydro-5-ethyluridine with an apparent Ki value of 25 nM. These compounds are selective inhibitors of uridine phosphorylase and have no effect on thymidine phosphorylase. 5-Substituted-2,2'-anhydrouridines are no substrates of either uridine phosphorylase or thymidine phosphorylase.
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