Hyaluronic acid based approaches for wound healing: A comprehensive review

Affiliations

¹ Department of Pharmaceutics, Bharti Vidyapeeth Deemed to be University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India.
² Alliance Management and Supply Chain, Azurity Pharmaceuticals, Inc., 8 Cabot Road, Suite 2000, Woburn, MA 01801, USA.
³ Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India; Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner 422608, Maharashtra, India.
⁴ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo 2007, Australia.
⁵ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; School of Medical and Life Sciences, Sunway University, 47500 Sunway City, Malaysia.
⁶ Department of Pharmaceutics, Institute of Pharmacy, Nirma University, S.G. Highway, Ahmedabad 382481, Gujarat, India.
⁷ Department of Pharmaceutical Chemistry, Vivekanand Education Society's College of Pharmacy, Chembur (East), Mumbai 400074, Maharashtra, India.
⁸ Department of Chemistry, Guru Nanak Khalsa College of Art Science and Commerce (Autonomus), Matunga (East), Mumbai 400019, Maharashtra, India.
⁹ Department of Pharmaceutics, Bharti Vidyapeeth Deemed to be University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India. Electronic address: amarjit.rajput@bharatividyapeeth.edu.

PMID: 40049471
DOI: 10.1016/j.ijbiomac.2025.141625

Hyaluronic acid based approaches for wound healing: A comprehensive review

Samay Parmal et al. Int J Biol Macromol. 2025 May.

. 2025 May;306(Pt 4):141625.

doi: 10.1016/j.ijbiomac.2025.141625. Epub 2025 Mar 4.

Authors

Affiliations

¹ Department of Pharmaceutics, Bharti Vidyapeeth Deemed to be University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India.
² Alliance Management and Supply Chain, Azurity Pharmaceuticals, Inc., 8 Cabot Road, Suite 2000, Woburn, MA 01801, USA.
³ Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India; Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner 422608, Maharashtra, India.
⁴ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo 2007, Australia.
⁵ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; School of Medical and Life Sciences, Sunway University, 47500 Sunway City, Malaysia.
⁶ Department of Pharmaceutics, Institute of Pharmacy, Nirma University, S.G. Highway, Ahmedabad 382481, Gujarat, India.
⁷ Department of Pharmaceutical Chemistry, Vivekanand Education Society's College of Pharmacy, Chembur (East), Mumbai 400074, Maharashtra, India.
⁸ Department of Chemistry, Guru Nanak Khalsa College of Art Science and Commerce (Autonomus), Matunga (East), Mumbai 400019, Maharashtra, India.
⁹ Department of Pharmaceutics, Bharti Vidyapeeth Deemed to be University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India. Electronic address: amarjit.rajput@bharatividyapeeth.edu.

PMID: 40049471
DOI: 10.1016/j.ijbiomac.2025.141625

Abstract

Wound healing is a natural, however complex, tissue repair and regeneration mechanism. Understanding the cascade of biological events associated with wound healing facilitates scientists in designing topical skin formulations with enhanced therapeutic outcomes. In recent years, several innovative approaches have been utilized to treat wounds. Hyaluronic acid (HA)-based formulations have shown promising results. The current manuscript provides a systematic review of various aspects of HA, including its structure, synthesis, mechanism involved in wound healing, and various formulations developed using HA to treat wounds. Covered are innovative treatment strategies explicitly emphasizing nanocarrier-based approaches. Various patents wherein HA has been used to treat wounds are also summarized with the help of a Google patent search. Diving deep, clinical perspectives, toxicity aspects, and application of computational chemistry in HA research are also discussed.

Keywords: Hyaluronic acid; Toxicity; Wound healing.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Hyaluronic acid based approaches for wound healing: A comprehensive review

Affiliations

Hyaluronic acid based approaches for wound healing: A comprehensive review

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

Substances

LinkOut - more resources

Full Text Sources