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Review
. 2025 Mar;39(3):281-284.
doi: 10.13201/j.issn.2096-7993.2025.03.019.

[Research progress of aldehyde dehydrogenase type 2 in head and neck malignant tumors]

[Article in Chinese]
Ying Li  1   2   3 , Taowei Wu  1   2   3 , Tan Cheng  1   2   3 , Ping Han  1   2   3
Affiliations
Review

[Research progress of aldehyde dehydrogenase type 2 in head and neck malignant tumors]

[Article in Chinese]
Ying Li et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 Mar.

Abstract
in English, Chinese

Alcohol is a high-risk factor of the head and neck tumor, and acetaldehyde dehydrogenase type 2（ALDH2） is an important alcohol metabolism enzyme in the human body, whose function is to metabolize acetaldehyde into non-toxic acetic acid in the human body. Studies have shown that ALDH2 gene polymorphisms increase the risk of head and neck tumors by affecting enzyme activity to regulate the rate of alcohol metabolism in the body, and high levels of ALDH2 expression are beneficial for enhancing head and neck tumor immunity and improve prognosis. This article aims to review the research progress on the relationship between ALDH2 and the occurrence and treatment of head and neck tumors.

摘要: 酒精是头颈恶性肿瘤的高危因素，乙醛脱氢酶2型（ALDH2）是人体内重要的酒精代谢酶，主要功能是将人体内的乙醛代谢成无毒的乙酸。已有研究证实ALDH2基因多态性通过影响酶活性来干扰体内酒精代谢速度从而增加罹患头颈恶性肿瘤的风险，而高水平的ALDH2表达则有利于增强头颈恶性肿瘤免疫及改善预后。本文旨在对ALDH2与头颈恶性肿瘤发生发展及治疗预后关系的研究进展做一综述。.

Keywords: ALDH2; alcohol; cancer therapy; head and neck tumor; immunity.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

References

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