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. 2025 Feb 12:67:177-182.
doi: 10.1016/j.jor.2025.02.006. eCollection 2025 Sep.

A therapeutic assessment of tranexamic acid on functional recovery after rotator cuff repair surgery: A study of early and mid-term follow-up

Jinkun Guo  1 , Meng Que  1 , Jinyan Guo  2 , ZhongFan Liu  3 , Yan-Jun Che  4
Affiliations

A therapeutic assessment of tranexamic acid on functional recovery after rotator cuff repair surgery: A study of early and mid-term follow-up

Jinkun Guo et al. J Orthop. .

Abstract

Purpose: To perform therapeutic assessment of tranexamic acid on functional recovery after rotator cuff repair surgery in terms of early and mid-term follow up.

Methods: From December 2021 to April 2023, a total of 40 patients with rotator cuff injury were enrolled and randomly assigned to two groups with equal number of patients, and all patients received shoulder arthroscopic surgery before receiving either tranexamic acid or normal saline managements. Patients in the experimental group, group A, treated with 2g tranexamic acid (diluted with normal saline to 20ml) via intra-articular injection, while patients in the control group (group B) received 20ml normal saline management. The whole process was conducted in accordance with randomized double-blind controlled trials. Clinical outcomes were assessed preoperatively and postoperatively via American Shoulder and Elbow Surgeons (ASES) score, a UCLA shoulder rating, a CONSTANT score, and visual analog scale (VAS). Early and mid-term follow-up were performed at 1 week, 1 month, 3 months, and 6 months after surgery.

Results: The ASES score and CONSTANT score at 1 month, 3 months and 6 months after operation in the tranexamic acid group were higher than those in the normal saline group (p < 0.05). Meanwhile, the UCLA score at 3 months and 6 months after operation in the tranexamic acid group was higher than that in the normal saline group (p < 0.05). In addition, the muscle strength score and external rotation value at 6 months after operation in the tranexamic acid group and normal saline group were higher than those in the normal saline group (p < 0.05). There was no significant difference in the VAS score between the two groups at each observation cut-off point (p > 0.05).

Conclusions: Injection of tranexamic acid after rotator cuff repair surgery plays an positive role on the recovery of patients muscle strength and tone as well as shoulder flexibility. Therapeutic assessment demonstrates the favorable clinic efficacy either early or mid-term follow-up.

Keywords: Rotator cuff injury; Shoulder arthroscopy; Synarthrophysi; Tranexamic acid.

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Conflict of interest statement

There is no conflict of interest between authors.

References

    1. Kuan F.C., Shih C.A., Su W.R., et al. Definition of irreparable rotator cuff tear: a scoping review of prospective surgical therapeutic trials to evaluate current practice. Patient. 2023;24:952. - PMC - PubMed
    1. Pogorzelski J., Erber B., Themessl A., et al. Definition of the terms “acute” and “traumatic” in rotator cuff injuries: a systematic review and call for standardization in nomenclature. Arch Orthop Trauma Surg. 2021;141(1):75–91. - PMC - PubMed
    1. Greenall G., Carr A., Beard D., et al. Systematic review of the surgical management of rotator cuff repair with an augmentative patch: a feasibility study protocol. Syst Rev. 2018;7(1):187. - PMC - PubMed
    1. Longo U.G., Risi Ambrogioni L., Berton A., et al. Conservative versus accelerated rehabilitation after rotator cuff repair: a systematic review and meta-analysis. BMC Muscoskelet Disord. 2021;22(1):637. - PMC - PubMed
    1. Adomavičienė A., Daunoravičienė K., Šidlauskaitė R., et al. Analysis of functional recovery and subjective well-being after arthroscopic rotator cuff repair. Medicina. 2021;57(7):715. - PMC - PubMed

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