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. 2025 Mar 5;85(3):282-310.
doi: 10.1055/a-2466-2778. eCollection 2025 Mar.

Early Pregnancy Loss in the 1st Trimester: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/076; August 2024)

Matthias David  1 , Nicolas von Ahsen  2 , Ibrahim Alkatout  3 , Franz Bahlmann  4 , Peter Martin Fehr  5 , Katharina Hancke  6 , Ruth Hiller  7 , Markus Hodel  8 , Markus Hoopmann  9 , Matthias Korell  10 , Gwendolin Manegold-Brauer  11 , Filiz Markfeld-Erol  12 , Annette M Müller  13 , Peter Oppelt  14 , Sabine Rudnik-Schöneborn  15 , Barbara Sonntag  16 , Susanne Starkmuth  17 , Axel Valet  18 , Stephanie Wallwiener  19 , Jan Weichert  20 , Simone Witzel  21 , Sven Becker  22
Affiliations

Early Pregnancy Loss in the 1st Trimester: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/076; August 2024)

Matthias David et al. Geburtshilfe Frauenheilkd. .

Abstract

Purpose This guideline aims to improve and standardize the diagnostic and therapeutic approaches for different types of miscarriages, pregnancies of unclear localization, and ectopic pregnancies in the 1st trimester. Methods In accordance with the requirements for an S2k-guideline, this guideline was compiled following a search of the literature, and the various recommendations and statements were formally agreed upon by an interdisciplinary group of representative experts from Germany (DGGG, etc.), Austria (OEGGG) and Switzerland (SGGG) who met up several times under the aegis of the German Society for Gynecology and Obstetrics ( Deutsche Gesellschaft für Gynäkologie und Geburtshilfe , DGGG). Recommendations The guideline provides 129 recommendations on clinical, laboratory-based, ultrasonographical, pathomorphological and genetic diagnostics and describes and assesses different therapeutic options in terms of their success and complication rates and the continued fertility of the patient as well as aspects of the grieving process and coming to terms with the loss after an early loss of pregnancy.

Keywords: ectopic pregnancy; guideline; miscarriage; pregnancy of unknown localization.

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Conflict of interest statement

Conflict of Interest The conflicts of interest of the authors are listed in the German-language long version of the guideline. Interessenkonflikt Die Interessenkonflikte der Autorinnen und Autoren sind in der Langfassung der Leitlinie aufgelistet.

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