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Observational Study
. 2025 Mar;60(3):e71030.
doi: 10.1002/ppul.71030.

Survey Health Data on Allergic Rhinitis (AR) and Asthmatic Symptoms and Blood Samples (IgE Sensitizations) in Preschool Children: An Observational Study

Susanne Kutzora  1   2 , Jonas Mehrl  2   3 , Jonas Huß  1 , Jeroen Buters  4 , Joana Candeias  4 , Renate Effner  4 , Lana Hendrowarsito  1 , Alisa Weinberger  1 , Caroline Quartucci  1   5 , Caroline Herr  1   5 , Stefanie Heinze  1   5 ; GME Study Group
Collaborators, Affiliations
Observational Study

Survey Health Data on Allergic Rhinitis (AR) and Asthmatic Symptoms and Blood Samples (IgE Sensitizations) in Preschool Children: An Observational Study

Susanne Kutzora et al. Pediatr Pulmonol. 2025 Mar.

Abstract

Background: Aim of the study was to investigate the association of IgE sensitizations in serum and self-reported allergic rhinitis (AR) and asthmatic symptoms.

Methods: Between 2015 and 2018, parents of 1190 children in Günzburg, Germany participated in the study by completing a questionnaire. Settings were the Health-Monitoring-Units (HMU) during the obligatory school entry examinations and a medical examination for all German children at the age of 60-64 months (U9). Random serum samples from 340 children were analyzed for IgE-sensitizations. For possible associations of sensitization and six health outcomes (symptoms of AR, dry cough at night, wheeze, asthma diagnosis, physician-diagnosed asthma, and physician-diagnosed AR), a regression analysis was performed.

Results: The parents of 1190 children completed the questionnaire. Parental asthma and physician-diagnosed asthma (OR 4.79; 95%-CI [2.16-10.65]) and underweight at birth/preterm delivery showed the highest associations with asthma based on the German ISAAC definition (OR 3.58; 95%-CI [1.77-7.22]). Out of 340 children blood samples 118 children were sensitized against at least one allergen (airborne pollen allergens, non-seasonal airborne allergens, or food allergens). Sensitized children reported more frequently from symptoms of AR, wheeze, and asthma based on the German ISAAC definition than children without sensitization.

Conclusion: This observational study identified the prevalence of AR, asthma and existing sensitization among the participating children. Parental asthma and underweight at birth were identified as risk factors for allergic symptoms and asthma.

Keywords: allergic rhinitis; allergy; children; health monitoring; sensitization.

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References

    1. C. Janeway, Immunobiology: The Immune System in Health and Disease, 5th ed. (Garland Publishing, 2001)
    1. Y. Schoefer, T. Schäfer, C. Meisinger, H.‐E. Wichmann, and J. Heinrich, “Predictivity of Allergic Sensitization (Rast) for the Onset of Allergic Diseases in Adults,” Allergy 63, no. 1 (2008): 81–86, https://doi.org/10.1111/j.1398-9995.2007.01517.x.
    1. K.‐C. Bergmann, J. Heinrich, and H. Niemann, “Aktueller Stand Zur Verbreitung Von Allergien in Deutschland,” Allergo Journal 25, no. 1 (2016): 22–26, https://doi.org/10.1007/s40629-016-0089-1.
    1. R. Thamm, I. Hey, and M. Thamm, “Epidemiologie allergischer Erkrankungen: Prävalenzen und Trends in Deutschland.” In Weißbuch Allergie in Deutschland, eds. L. Klimek, C. Vogelberg and T. Werfel. (Springer, 2019), 27–51).
    1. C. Poethko‐Müller, M. Thamm, and R. Thamm, “Heuschnupfen und Asthma bei Kindern und Jugendlichen in Deutschland—Querschnittergebnisse aus KiGGS Welle 2 Trends,” In Journal of Health Monitoring: KiGGS Welle 2—Erste Ergebnisse aus Querschnitt‐ und Kohortenanalysen. RKI‐Bib1 (Robert Koch‐Institut), ed. R. Koch‐Institut, (2018), 55–59.

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