Orientin: a comprehensive review of a promising bioactive flavonoid

Abstract

Medicinal herbs continue to play an important part in modern drugs and healthcare because customers think that most of them have fewer or milder side effects than traditional modern medicines. Bioactive compounds are typically isolated from plants before being used as a source of therapeutic medicines. As a result, extracting bioactive compounds from medicinal plants is an important step in developing plant-based medications. Orientin is a flavonoid C-glycoside found in many plants, is frequently used in bioactivity studies due to its numerous beneficial properties, which include antioxidants, antiaging, anti-inflammation, vasodilation and cardioprotective, neuroprotective, antidiabetic, hepatoprotective, and adaptogenic effects. In this review, the comprehensive search for the health benefits of orientin was traced. The findings reflected that orientin could be considered one of the important natural candidates as a potential nutraceutical. This underscores its promising attributes and potential applications in health and wellness. Further research may be guaranteed to fully elucidate its benefits and mechanisms of action.

Keywords: Flavonoid C-glycoside; Orientin; Pharmacological activities.

Fig. 1

Chemical structure of orientin

Fig. 2

Neuroprotective effect of orientin

Fig. 3

Hepatoprotective effects of orientin

Fig. 4

Illustration of various cancer types managed by orientin (A) and orientin mechanisms of action in alleviating cancer (B)