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Review
. 2025 Jun;1871(5):167783.
doi: 10.1016/j.bbadis.2025.167783. Epub 2025 Mar 6.

Micro-RNAs targeting the estrogen receptor alpha involved in endocrine therapy resistance in breast cancer

J M Márquez-Mendoza  1 , N Baranda-Ávila  2 , M Lizano  3 , E Langley  4
Affiliations
Review

Micro-RNAs targeting the estrogen receptor alpha involved in endocrine therapy resistance in breast cancer

J M Márquez-Mendoza et al. Biochim Biophys Acta Mol Basis Dis. 2025 Jun.

Abstract

Endocrine therapy resistance (ETR) in breast cancer (BC) is a multicausal phenomenon with diverse alterations in the tumor cell interactome. Within these alterations, non-coding RNAs (ncRNAs) such as micro-RNAs (miRNAs) modulate the expression of tumor suppressor genes and proto-oncogenes, such as the ESR1 gene encoding estrogen receptor alpha (ERα). This work aims to review the effects of miRNAs targeting ERα mRNA and their mechanisms related to ETR in BC. A thorough review of the literature and an in silico study were carried out to elucidate the involvement of each miRNA, thus contributing to the understanding of ETR in BC.

Keywords: Breast cancer; Endocrine therapy resistance; Estrogen receptor alpha; Noncoding RNAs; micro-RNAs.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The figures in this publication were created with BioRender.com.

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