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. 2025 Apr;46(4):295-297.
doi: 10.1016/j.tips.2025.02.007. Epub 2025 Mar 8.

A mechanism for ligand-dependent activation of AHR

Audrey Guesdon  1 , William Bourguet  2
Affiliations

A mechanism for ligand-dependent activation of AHR

Audrey Guesdon et al. Trends Pharmacol Sci. 2025 Apr.

Abstract

The aryl hydrocarbon receptor (AHR) is a crucial chemosensory protein and an emerging therapeutic target. However, the lack of structural data has long hindered a complete understanding of the mechanisms driving its function. Recently, Wu and colleagues reported a structural analysis of various DNA-bound AHR-ligand complexes, suggesting a ligand-driven activation mechanism.

Keywords: AHR nuclear translocator; X-ray structure; aryl hydrocarbon receptor; heterodimer; ligand; xenobiotics.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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