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. 1985 Aug 1;56(3):457-60.
doi: 10.1002/1097-0142(19850801)56:3<457::aid-cncr2820560307>3.0.co;2-7.

A phase II study of high-dose estrogens (diethylstilbestrol diphosphate) in prostate cancer

D L Citrin, M S Kies, C B Wallemark, J Khandekar, E Kaplan, F Camacho, R Lind

A phase II study of high-dose estrogens (diethylstilbestrol diphosphate) in prostate cancer

D L Citrin et al. Cancer. .

Abstract

Twenty-five patients with metastatic prostate cancer resistant to primary hormone therapy, received high-dose intravenous diethylstilbestrol diphosphate (Stilphostrol [Miles Pharm], DES-P) in a Phase II study using established response criteria. Objective response rate was 17%, while 22% of the patients were subjectively improved. Moderate gastrointestinal toxicity was reported in 10 patients (40%). Thromboembolic complications were seen in 2 (8%). The role of high-dose Stilphostrol in the treatment of hormone-resistant prostate cancer is limited.

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