Precision oncology - Guideline of the Austrian, German and Swiss Societies for hematology and medical oncology

Damian T Rieke¹, Michael Bitzer², Annalen Bleckmann³, Alexander Desuki⁴, Thomas Ernst⁵, Irene Esposito⁶, Armin Gerger⁷, Hanno Glimm⁸, Peter Horak⁹, Daniel Hübschmann¹⁰, Anna Lena Illert¹¹, Volker Kunzmann¹², Sonja Loges¹³, Ina Pretzell¹⁴, Katja Schmitz¹⁵, Andreas Seeber¹⁶, Bärbel Söhlke¹⁷, Andreas Wicki¹⁸, Jürgen Wolf¹⁹, Georg Maschmeyer²⁰

Affiliations

¹ Comprehensive Cancer Center and Department for Hematology, Oncology and Cancer Immunology Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany. Electronic address: damian.rieke@charite.de.
² Department of Internal Medicine I, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany.
³ Department of Medicine A, Hematology, Oncology and Pneumology, West German Cancer Center, University Hospital Muenster, Muenster, Germany.
⁴ University Cancer Center Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
⁵ Department of Hematology/Oncology, Clinic of Internal Medicine II, Jena University Hospital, Jena, Germany.
⁶ Institute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Dusseldorf, Germany.
⁷ Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
⁸ Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
⁹ Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ Center for Personalized Medicine (ZPM), Technical University of Munich (TUM), School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Munich, Germany.
¹² Department of Internal Medicine II, Medical Oncology, Comprehensive Cancer Center Mainfranken Würzburg, University Hospital Würzburg, Germany.
¹³ DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
¹⁴ West German Cancer Center, University Hospital Essen, Essen, Germany.
¹⁵ Tyrolpath Obrist Brunhuber GmbH and Krankenhaus St. Vinzenz, Zams, Austria.
¹⁶ Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
¹⁷ Zielgenau e.V. Patient network for personalized lung cancer therapy, Kerpener Str. 6250937 Cologne, Germany.
¹⁸ Department of Medical Oncology and Hematology, University Hospital of Zurich, Switzerland; University of Zurich, Switzerland.
¹⁹ Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
²⁰ Deutsche Gesellschaft für Hämatologie und medizinische Onkologie e.V., Bauhofstr. 12, Berlin 10117, Germany.

PMID: 40058270
DOI: 10.1016/j.ejca.2025.115331

Free article

Practice Guideline

Precision oncology - Guideline of the Austrian, German and Swiss Societies for hematology and medical oncology

Damian T Rieke et al. Eur J Cancer. 2025.

Free article

. 2025 May 2:220:115331.

doi: 10.1016/j.ejca.2025.115331. Epub 2025 Feb 28.

Authors

Affiliations

¹ Comprehensive Cancer Center and Department for Hematology, Oncology and Cancer Immunology Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany. Electronic address: damian.rieke@charite.de.
² Department of Internal Medicine I, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany.
³ Department of Medicine A, Hematology, Oncology and Pneumology, West German Cancer Center, University Hospital Muenster, Muenster, Germany.
⁴ University Cancer Center Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
⁵ Department of Hematology/Oncology, Clinic of Internal Medicine II, Jena University Hospital, Jena, Germany.
⁶ Institute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Dusseldorf, Germany.
⁷ Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
⁸ Department for Translational Medical Oncology, National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
⁹ Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ Center for Personalized Medicine (ZPM), Technical University of Munich (TUM), School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Munich, Germany.
¹² Department of Internal Medicine II, Medical Oncology, Comprehensive Cancer Center Mainfranken Würzburg, University Hospital Würzburg, Germany.
¹³ DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, Department of Personalized Oncology, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
¹⁴ West German Cancer Center, University Hospital Essen, Essen, Germany.
¹⁵ Tyrolpath Obrist Brunhuber GmbH and Krankenhaus St. Vinzenz, Zams, Austria.
¹⁶ Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
¹⁷ Zielgenau e.V. Patient network for personalized lung cancer therapy, Kerpener Str. 6250937 Cologne, Germany.
¹⁸ Department of Medical Oncology and Hematology, University Hospital of Zurich, Switzerland; University of Zurich, Switzerland.
¹⁹ Department of Internal Medicine, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
²⁰ Deutsche Gesellschaft für Hämatologie und medizinische Onkologie e.V., Bauhofstr. 12, Berlin 10117, Germany.

PMID: 40058270
DOI: 10.1016/j.ejca.2025.115331

Abstract

Precision oncology is a multi-step process including patient selection, tumor profiling, molecular tumor board discussion and personalized cancer management. So far, it remains largely unstandardized. The implementation of precision oncology can be beneficial for patients but implementation differs widely between tumor types and local practices. A working group was established by the Austrian, German and Swiss societies for Hematology and Medical Oncology to establish an expert consensus on evidence-based standards and implementation of precision oncology. Herein, we present a summary of this guideline. The full documents are available at www.onkopedia-guidelines.info.

Keywords: Molecular Oncology; Personalized medicine; Precision Oncology; Targeted therapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:

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Precision oncology - Guideline of the Austrian, German and Swiss Societies for hematology and medical oncology

Affiliations

Precision oncology - Guideline of the Austrian, German and Swiss Societies for hematology and medical oncology

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical