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. 2025 Jan 14;46(1):5-8.
doi: 10.3760/cma.j.cn121090-20241228-00600.

[The state of the art: diagnosis and therapeutic interventions of clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance]

[Article in Chinese]
Z J Xiao  1
Affiliations

[The state of the art: diagnosis and therapeutic interventions of clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance]

[Article in Chinese]
Z J Xiao. Zhonghua Xue Ye Xue Za Zhi. .

Abstract
in English, Chinese

Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS) are included in both fifth edition of the World Health Organization classification (WHO 2022) and International Consensus Classification (ICC). Recently three models were developed for prediction of myeloid neoplasms risk and clinical trials are initiated to investigate potential treatments for CHIP and CCUS. Challenges in diagnosis and therapeutic intervention of CHIP and CCUS were discussed.

2022年提出的造血淋巴肿瘤WHO分型（WHO 2022）以及髓系肿瘤和急性白血病国际共识分型（ICC）已将潜质未定的克隆性造血（CHIP）和意义未定的克隆性血细胞减少症（CCUS）正式列入了髓系肿瘤分型。最近又相继提出了三个CHIP和CCUS髓系肿瘤转化分险的预测模型，并已开展了CHIP和CCUS干预治疗临床试验。为了规范CHIP和CCUS的诊断和治疗，本文就目前我国面临的挑战以及可能的解决方案做了探讨。.

Keywords: Clonal cytopenias of undetermined significance; Clonal hematopoiesis; Clonal hematopoiesis of indeterminate potential; Diagnosis; Treatment.

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