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Editorial
. 2025 Mar 9;14(1):99652.
doi: 10.5409/wjcp.v14.i1.99652.

Selenoprotein P1 as a biomarker of insulin resistance in pediatric obesity: Insights and implications

Chun-Han Cheng  1 , Wen-Rui Hao  2   3 , Tzu-Hurng Cheng  4
Affiliations
Editorial

Selenoprotein P1 as a biomarker of insulin resistance in pediatric obesity: Insights and implications

Chun-Han Cheng et al. World J Clin Pediatr. .

Abstract

This editorial discusses the findings of Elbarky et al on the role of selenoprotein P1 (SEPP1) in pediatric obesity and insulin resistance. Their study uncovered significantly lower SEPP1 Levels in children who were obese compared with healthy peers, demonstrating a negative correlation between SEPP1 levels and measures of adiposity and insulin resistance. These findings suggest that SEPP1 is a biomarker useful in the early identification of insulin resistance in pediatric populations. This editorial emphasizes the clinical implications of the study and calls for further research to validate and explore the role of SEPP1 in metabolic health.

Keywords: Biomarkers; Insulin resistance; Metabolic health; Pediatric obesity; Selenoprotein P1.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare having no conflicts of interest.

References

    1. Elbarky A, Ismail KG, Yousef YF, Elshafiey RMG, Elsharaby RM, El-Kaffas A, Al-Beltagi M. Selenoprotein-p and insulin resistance in children and adolescents with obesity. World J Clin Pediatr. 2024;13:94721. - PMC - PubMed
    1. Casanova P, Monleon D. Role of selenium in type 2 diabetes, insulin resistance and insulin secretion. World J Diabetes. 2023;14:147–158. - PMC - PubMed
    1. Huang YC, Wu TL, Zeng H, Cheng WH. Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice. J Nutr. 2021;151:1894–1900. - PMC - PubMed
    1. Ogino H, Murano K, Okuno T, Ueno H. Relationship between Serum Concentrations and Muscular Expressions of Selenoproteins on Selenium-Supplemented Insulin Resistance Mouse Model. Biol Pharm Bull. 2024;47:1000–1007. - PubMed
    1. di Giuseppe R, Koch M, Schlesinger S, Borggrefe J, Both M, Müller HP, Kassubek J, Jacobs G, Nöthlings U, Lieb W. Circulating selenoprotein P levels in relation to MRI-derived body fat volumes, liver fat content, and metabolic disorders. Obesity (Silver Spring) 2017;25:1128–1135. - PubMed

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