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. 2024 Dec 12;39(4):522-528.
doi: 10.46497/ArchRheumatol.2024.10557. eCollection 2024 Dec.

Fecal calprotectin levels in patients with fibromyalgia: A cross-sectional study

Ece Çınar  1 , Meryem Burcu Türkoğlu Aytar  2 , Musa Baklacı  3 , Simin Hepgüler  1 , Burcu Barutçuoğlu  4
Affiliations

Fecal calprotectin levels in patients with fibromyalgia: A cross-sectional study

Ece Çınar et al. Arch Rheumatol. .

Abstract

Objectives: This study aimed to evaluate levels of fecal calprotectin (FC), a biomarker that helps distinguish irritable bowel syndrome from inflammatory gut disorders, in patients with fibromyalgia syndrome (FMS) and compare them to healthy controls.

Patients and methods: The cross-sectional study was carried out on patients diagnosed with FMS according to the ACR (American College of Rheumatology) 2016 classification and healthy controls between January 2021 and February 2022. FMS patients were grouped according to the absence (Group 1) or presence (Group 2) of gastrointestinal symptoms. A third group of healthy controls without gastrointestinal complaints (Group 3) was included. Demographic data, comorbidities, medications, symptom severity scale, and widespread pain index scores were recorded. All subjects were asked to provide stool samples for the measurement of FC levels.

Results: A total of 100 subjects were included in the study. There were 33 patients (4 males, 29 females, mean age: 46.9±10.6; range, 22 to 69 years) in Group 1, 32 patients (2 males, 30 females, mean age: 48.5±11.0; range, 22 to 73 years) in Group 2, and 35 patients (11 males, 24 females, mean age: 39.2±13.1; range, 22 to 67 years) in Group 3. Group 2 had significantly higher levels of FC compared to Group 3 (p <0.05). The number of patients with positive FC values was similar between the three groups. Symptom severity scale and widespread pain index scores were significantly worse in Group 2 compared to Group 1 (p <0.05).

Conclusion: Irritable bowel syndrome usually coexists in many patients with FMS, and this may cause a misdiagnosis or delay in the diagnosis of organic gastrointestinal conditions. The value of FC in screening and diagnosis of organic disease in FMS patients needs further evaluation.

Keywords: Abdominal pain; fecal calprotectin; fibromyalgia syndrome; irritable bowel syndrome..

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Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. Flowchart of the study.
See this image and copyright information in PMC

References

    1. Häuser W, Sarzi-Puttini P, Fitzcharles MA. Fibromyalgia syndrome: Under-, over- and misdiagnosis. Clin Exp Rheumatol. 2019;37 Suppl 116:90–97. - PubMed
    1. Kleykamp BA, Ferguson MC, McNicol E, Bixho I, Arnold LM, Edwards RR, et al. The prevalence of psychiatric and chronic pain comorbidities in fibromyalgia: An ACTTION systematic review. Semin Arthritis Rheum. 2021;51:166–174. doi: 10.1016/j.semarthrit.2020.10.006. - DOI - PubMed
    1. Guo J, Pei L, Chen L, Chen H, Gu D, Peng Y, et al. Bidirectional association between irritable bowel syndrome and restless legs syndrome: A systematic review and meta-analysis. Sleep Med. 2021;77:104–111. doi: 10.1016/j.sleep.2020.12.002. - DOI - PubMed
    1. Gemignani F. Irritable bowel syndrome, restless legs syndrome, small fiber neuropathy, and fibromyalgia. Sleep Med. 2021;83:4–4. doi: 10.1016/j.sleep.2021.04.023. - DOI - PubMed
    1. Erdrich S, Hawrelak JA, Myers SP, Harnett JE. A systematic review of the association between fibromyalgia and functional gastrointestinal disorders. Therap Adv Gastroenterol. 2020;13:1756284820977402–1756284820977402. doi: 10.1177/1756284820977402. - DOI - PMC - PubMed

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