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Case Reports
. 2025 Feb 1;28(2):124-128.
doi: 10.34172/aim.28751. Epub 2025 Feb 1.

Lactating Adenoma in Pregnancy: Report of Three Cases

Julija Cvetković  1 , Maja Jovičić Milentijević  1 , Nikola Živković  1 , Miodrag Đorđević  2 , Jelena Grujović  1 , Goran Radenković  3
Affiliations
Case Reports

Lactating Adenoma in Pregnancy: Report of Three Cases

Julija Cvetković et al. Arch Iran Med. .

Abstract

Background: Lactating adenoma is an infrequent benign stromal breast tumor mostly seen during pregnancy and lactation. This report seeks to enhance the literature by presenting three cases diagnosed with this condition, while also highlighting its histological subtypes, immunohistochemical characteristics, and differential diagnoses. Case Presentation: In all three patients, a circumscribed, painless, and mobile mass was found in the breast in the third trimester of pregnancy. Pathohistological examination revealed hyperplastic lobules with glandular formations in back-to-back arrangements showing more or less abundant hobnailing phenomena with intraluminal eosinophilic secretions and inconspicuous myoepithelial cell layer separated by fibrovascular stroma. The immune profile showed positive reaction for cytokeratin 14 and p40 markers, indicating the presence of myoepithelial cells and distinguishing these cases from other breast lesions.

Conclusion: Pathohistological and immunohistochemical analysis should be performed to differentiate these lesions from other benign lesions and malignant tumors.

Keywords: Adenoma; Breast; Case reports; Lactation; Pregnancy.

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Conflict of interest statement

Competing Interests

The authors declare that they have no competing interests.

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