Awake Prone Positioning in COVID-19-Is There a New Standard of Care?

Affiliations

¹ Cardiovascular Research Institute, Departments of Medicine and Anesthesia, University of California, San Francisco.
² Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota School of Medicine, Minneapolis.
³ Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco.

Michael A Matthay et al. JAMA Intern Med. 2025.

. 2025 May 1;185(5):581-582.

doi: 10.1001/jamainternmed.2025.0021.

¹ Cardiovascular Research Institute, Departments of Medicine and Anesthesia, University of California, San Francisco.
² Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota School of Medicine, Minneapolis.
³ Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco.

No abstract available

Comment in

Awake Prone Positioning in Adults With COVID-19: An Individual Participant Data Meta-Analysis.
Luo J, Pavlov I, Tavernier E, Perez Y, Kharat A, McNicholas B, Roca O, Vines DL, Ibarra-Estrada M, Alhazzani W, Lewis K, Simpson SQ, Rampon G, Liu L, Sun Q, Qiu H, Yang Y, Lapadula G, Qian ET, Gatto CL, Rice TW, Parhar KKS, Weatherald J, Walkey AJ, Bosch NA, Nay MA, Boulain T, Fossat G, Harris TRE, Thwaites CL, Phong NT, Bonfanti P, Yarahmadi S, Hashemian SM, Jayakumar D, Taylor SP, Johnson SA, Guerin C, Laffey JG, Ehrmann S, Li J; Awake Prone Positioning Meta-Analysis Group. Luo J, et al. JAMA Intern Med. 2025 May 1;185(5):572-581. doi: 10.1001/jamainternmed.2025.0011. JAMA Intern Med. 2025. PMID: 40063016

1. Luo J, Pavlov I, Tavernier E, et al. Awake prone positioning in adults with COVID-19: an individual participant data meta-analysis. JAMA Intern Med Published online March 10, 2025. doi: 10.1001/jamainternmed.2025.0011 - DOI - PMC - PubMed
1. Gattinoni L, Pelosi P, Vitale G, Pesenti A, D’Andrea L, Mascheroni D Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure. Anesthesiology. 1991;74(1):15–23. doi: 10.1097/00000542-199101000-00004 - DOI - PubMed
1. Guérin C, Reignier J, Richard JC, et al. ; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013;368(23):2159–2168. doi: 10.1056/NEJMoa1214103 - DOI - PubMed
1. Guérin C, Albert RK, Beitler J, et al. Prone position in ARDS patients: why, when, how and for whom. Intensive Care Med 2020;46(12):2385–2396. doi: 10.1007/s00134-020-06306-w - DOI - PMC - PubMed
1. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest 2012;122(8):2731–2740. doi: 10.1172/JCI60331 - DOI - PMC - PubMed