Disclosure The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: MGP: no disclosures MGdH: Travel and accommodation: Novartis, Pfizer; Invited speaker: Ipsen JCL: Travel, Accommodations, Expenses: Rovi, Pierre Fabre TG: Lectures/Honoraria: GSK; Travel/Accommodation/Expenses: Pfizer, Pierre-Fabre, MSD, BMS PG: Consultancy/honoraria from AbbVie, Amgen, AstraZeneca, Bayer, BMS, Boehringer Ingelheim, Daiichi Sankyo, GlaxoSmithKline, Johnson and Johnson, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi and Takeda VAA: Payment or honoraria: Takeda, Roche, BMS, MSD. Support for attending meetings and/or travel: Roche, MSD, Janssen CT: Grants/research support: Novartis; Honoraria or consultation fees: AstraZeneca, Novartis, MSD; Lectures and educational activities: Biocartis, Roche, AstraZeneca; Other support /potential conflict of interest: Travel, Accommodations, Expenses: Lilly, MSD, AstraZeneca NR: Advisory Board: AbbVie, Amgen, AstraZeneca, Bayer, Boehringer, Janssen, MSD, Novartis, Pfizer, Roche, Sanofi, Takeda; Invited Speaker: Amgen, AstraZeneca, BMS, Merck, MSD, Novartis, Sanofi; Expert Testimony: Janssen, Merck, Medscape and Touch Medical. Steering Committee: Novartis, IO Biotech, and Johnson and Johnson. AN: Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Takeda Roche, BMS, Tecnofarma, Pfizer, BMS; Payment for expert testimony: MedSIR; Support for attending meetings and/or travel: Roche, Takeda, Janssen; Participation on a Data Safety Monitoring Board or Advisory Board: Boehringer Ingelheim, Janssen, Amgen, Hengenix Biotech, Oryzon Genomics, AstraZeneca MN: current shareholder and employee of NeoGenomics DP: Consulting, advisory role or lectures: AstraZeneca, Abbvie, Bristol-Myers Squibb, Bohringer Ingelheim, Celgene, Daiichi Sankyo, Eli Lilly, Merck, Novartis, Janssen, Pfizer, Roche, Pierre-fabre, Takeda, ArriVent, Mirati, Seagen, GSK. Travel, Accommodations, Expenses: AstraZeneca, Roche, Novartis, Pfizer NL: none relevant; Institutional grant funding: AZ, Lilly, Neogenomics, Merck, Pfizer, GSK;Travel funding (CME lectures): AZ, Guardant Health, Janssen, MSD, Roche, Sanofi LM: Grants/research support: Amgen, Inivata, AstraZeneca, Gilead; Honoraria or consultation fees: Roche, Takeda, Janssen, MSD; Lectures and educational activities: Bristol-Myers Squibb, AstraZeneca, Roche, Takeda, Janssen, MSD, Radonova, Janssen. Other support / potential conflict of interest: Travel, Accommodations, Expenses: Bristol-Myers Squibb, Roche, Takeda, AstraZeneca, Janssen. The rest of authors do not have any disclosures to declare.