Addressing infectious challenges in pediatric cancer and hematopoietic cell transplantation: insights from the Umbrella Working Group

Luise Martin^{1

2}, Fabianne Carlesse^{3

4}, Caitlin W Elgarten⁵, Andreas H Groll⁶, Christa Koenig⁷, Maria Kourti⁸, Jessica E Morgan^{9

10}, Zoi-Dorothea Pana¹¹, Loizos Petrikkos^{12

13}, Bob Phillips^{9

10}, Athanasios Tragiannidis⁸, Eleana Vasileiadi¹⁴, Roland A Ammann^{15

16}, Eva Brack⁷, L Lee Dupuis^{17

18

19}, Daniel Ebrahimi-Fakhari⁶, Alessio Mesini²⁰, Galina Solopova²¹, Lillian Sung²², Nadja Vissing²³, Thomas Lehrnbecher²⁴

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Medical Directorate, Berlin, Germany.
² Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
³ Oncology Pediatric Institute - IOP-GRAACC-UNIFESP, São Paulo, Brazil.
⁴ Federal University of São Paulo, São Paulo, Brazil.
⁵ Division of Oncology, Children'S Hospital of Philadelphia, Philadelphia, USA.
⁶ Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, University Children'S Hospital, Münster, Germany.
⁷ Pediatric Hematology/Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁸ Pediatric & Adolescent Hematology Oncology Unit, 2nd Pediatric Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
⁹ Candlelighters Supportive Care Research Centre, Centre for Reviews and Dissemination, University of York, York, UK.
¹⁰ Department of Paediatric Haematology and Oncology, Leeds Children'S Hospital, Leeds, UK.
¹¹ Medical School, University of Nicosia (UNIC), Nicosia, Cyprus.
¹² Department of Nursing, University of West Attica, Athens, Greece.
¹³ Pediatric Ambulatory Care - 1, Health Authority, Attica, NHS, Greece.
¹⁴ Division of Infectious Disease, Department of Pediatrics, Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁵ Medical Faculty, University of Bern, Bern, Switzerland.
¹⁶ Statconsult Ammann, Burgdorf, Switzerland.
¹⁷ Research Insititute, the Hospital for Sick Children, Toronto, ON, Canada.
¹⁸ Department of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁹ Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
²⁰ Infectious Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
²¹ Infection Control Department, Dmitry Rogachev National Medical Research Center for Pediatric Oncology, Hematology and Immunology, Moscow, Russia.
²² Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
²³ Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
²⁴ Department of Pediatrics, Division of Hematology, Oncology and Hemostaseology, Goethe University Frankfurt, Theodor-Stern Kai 7, 60590, Frankfurt/Main, Germany. Thomas_Lehrnbecher@yahoo.com.

PMID: 40064695
PMCID: PMC11893659
DOI: 10.1007/s00520-025-09337-5

Addressing infectious challenges in pediatric cancer and hematopoietic cell transplantation: insights from the Umbrella Working Group

Luise Martin et al. Support Care Cancer. 2025.

. 2025 Mar 11;33(4):264.

doi: 10.1007/s00520-025-09337-5.

Authors

Affiliations

¹ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Medical Directorate, Berlin, Germany.
² Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
³ Oncology Pediatric Institute - IOP-GRAACC-UNIFESP, São Paulo, Brazil.
⁴ Federal University of São Paulo, São Paulo, Brazil.
⁵ Division of Oncology, Children'S Hospital of Philadelphia, Philadelphia, USA.
⁶ Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, University Children'S Hospital, Münster, Germany.
⁷ Pediatric Hematology/Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁸ Pediatric & Adolescent Hematology Oncology Unit, 2nd Pediatric Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
⁹ Candlelighters Supportive Care Research Centre, Centre for Reviews and Dissemination, University of York, York, UK.
¹⁰ Department of Paediatric Haematology and Oncology, Leeds Children'S Hospital, Leeds, UK.
¹¹ Medical School, University of Nicosia (UNIC), Nicosia, Cyprus.
¹² Department of Nursing, University of West Attica, Athens, Greece.
¹³ Pediatric Ambulatory Care - 1, Health Authority, Attica, NHS, Greece.
¹⁴ Division of Infectious Disease, Department of Pediatrics, Children'S Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁵ Medical Faculty, University of Bern, Bern, Switzerland.
¹⁶ Statconsult Ammann, Burgdorf, Switzerland.
¹⁷ Research Insititute, the Hospital for Sick Children, Toronto, ON, Canada.
¹⁸ Department of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁹ Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
²⁰ Infectious Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
²¹ Infection Control Department, Dmitry Rogachev National Medical Research Center for Pediatric Oncology, Hematology and Immunology, Moscow, Russia.
²² Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
²³ Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
²⁴ Department of Pediatrics, Division of Hematology, Oncology and Hemostaseology, Goethe University Frankfurt, Theodor-Stern Kai 7, 60590, Frankfurt/Main, Germany. Thomas_Lehrnbecher@yahoo.com.

PMID: 40064695
PMCID: PMC11893659
DOI: 10.1007/s00520-025-09337-5

No abstract available

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Conflict of interest statement

Declarations. Competing interests: L. Lee Dupuis is a Deputy Associate Editor of Supportive Care in Cancer, Thomas Lehrnbecher an Editorial Consultant of the journal.

References

1. Lehrnbecher T et al (2023) Invasive fungal diseases impact on outcome of childhood ALL - an analysis of the international trial AIEOP-BFM ALL 2009. Leukemia 37(1):72–78 - PMC - PubMed
1. Groll AH et al (2021) 8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation. Lancet Oncol 22(6):254-269. 10.1016/S1470-2045(20)30723-3 - PubMed
1. Lehrnbecher T et al (2021) 8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation. Lancet Oncol 22(6):e270-e280. 10.1016/S1470-2045(20)30725-7 - PubMed
1. Lehrnbecher T et al (2012) Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation. J Clin Oncol 30(35):4427–4438 - PubMed
1. Lehrnbecher T et al (2017) Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update. J Clin Oncol 35(18):2082–2094 - PubMed

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Addressing infectious challenges in pediatric cancer and hematopoietic cell transplantation: insights from the Umbrella Working Group

Affiliations

Addressing infectious challenges in pediatric cancer and hematopoietic cell transplantation: insights from the Umbrella Working Group

Authors

Affiliations

Conflict of interest statement

References

Publication types

LinkOut - more resources

Full Text Sources