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Review
. 2025 Aug;39(8):1395-1409.
doi: 10.1111/jdv.20607. Epub 2025 Mar 11.

Cumulative life course impairment: Evidence for hidradenitis suppurativa

Maneli Doroudian Tehrani  1 , Ruby S Gibson  2 , Corey L Snyder  3 , Martina L Porter  1 , Alexa B Kimball  1
Affiliations
Review

Cumulative life course impairment: Evidence for hidradenitis suppurativa

Maneli Doroudian Tehrani et al. J Eur Acad Dermatol Venereol. 2025 Aug.

Abstract

Hidradenitis suppurativa (HS) adversely affects quality of life, education, work, relationships and mental health. The debilitating effects of HS can compound over a patient's lifetime and have lasting repercussions. The cumulative life course impairment (CLCI) model analyses the disease factors that could affect the life course trajectory of a patient, including effects on major life decisions and opportunities, such as relationships, career path, education and starting a family. As with other diseases, direct longitudinal data for CLCI would require large long cohort studies. Nonetheless, the evidence supports that common domains delineated in the CLCI document impact that are consistent with the negative impact of HS on life course.

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Conflict of interest statement

Dr. Kimball is receiving honoraria or consulting with Abbvie, Alumis, Avalo, Boehringer Ingelheim, Eli Lilly, Evoimmune, Innovaderm, Janssen, Merck, Moonlake, Novartis, Pfizer, Priovant, Sanofi, Sonoma Bio, Target RWE, UCB, Union Therapeutics and Takeda. Dr. Kimball is on the board of directors of Almirall and the American Dermatologic Association. Dr. Kimball's institution receives grants from: Abbvie, Anapyts Bio, Aristea, Bristol Myers Squibb, Eli Lilly, Incyte, Janssen, Moonlake, Novartis, Pfizer, Prometheus, Sanofi, Sonoma Bio, UCB. Dr. Porter is a consultant and/or investigator for Abbvie, Anapyts Bio, Aristea, Bristol Myers Squibb, Eli Lilly, Incyte, Janssen, Moonlake, Novartis, Pfizer, Prometheus, Sanofi, Sonoma Bio, UCB, Regeneron, Bayer, Alumis, Avalo, Trifecta Clinical/WCG, Zurabio. Dr. Porter receives royalties from BIDMC Licensed HS training module. She is a member of the AAD Patient Safety Quality Committee, HS Foundation Research and Therapeutics Committee, and AAD DataDerm Committee. Dr. Gibson's fellowship was funded through the National Psoriasis Foundation. Dr. Doroudian Tehrani is an investigator for Abbvie, Eli Lilly, Incyte, Moonlake, Prometheus, Sanofi, Insmed, UCB and Bristol Myers Squibb. Corey Snyder has no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
PRISMA diagram of literature review.
See this image and copyright information in PMC

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