Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May;27(5):231-238.
doi: 10.1007/s11920-025-01593-w. Epub 2025 Mar 11.

Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD): Building a Global Consortium Benefiting People with Bipolar Disorder in Later Life

Melis Orhan #  1 , Laura Montejo #  2 , Martha Sajatovic  3 , Lisa Eyler #  4   5 , Annemiek Dols #  6
Affiliations
Review

Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD): Building a Global Consortium Benefiting People with Bipolar Disorder in Later Life

Melis Orhan et al. Curr Psychiatry Rep. 2025 May.

Abstract

Purpose of review: Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) project, including sociodemographic and clinical information from older age bipolar disorder (OABD) and healthy participants around the globe (approximately N = 5000) were reviewed. Data was collected in multiple waves to create a large integrated dataset.

Recent findings: BD does not seem to fade with age. BD subtype and early/late onset did not show significant differences in daily functioning. Physical comorbidities were more frequent in OABD compared with controls. Women with OABD had an earlier age at onset and more psychiatric hospitalizations. GAGE-BD is the largest OABD cohort. Dataset results offer a unique and comprehensive resource for understanding the long-term trajectory of BD and the specific needs of this population. Findings are vital for guiding future research and improving care strategies for aging individuals with BD.

Keywords: Aging; Bipolar disorder; Global dataset; Older adults; Older age.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests.

References

    1. World Health Organization. World population ageing, 1950–2050. New York: United Nations. 2002. https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.... Accessed 4 September 2024.
    1. Sajatovic M, Blow FC, Ignacio RV, Kales HC. Age-related modifiers of clinical presentation and health service use among veterans with bipolar disorder. Psychiatr Serv Wash DC. 2004;55:1014–21. - PubMed
    1. Sajatovic M, Strejilevich SA, Gildengers AG, et al. A report on older-age bipolar disorder from the international society for bipolar disorders task force. Bipolar Disord. 2015;17:689–704. - PMC - PubMed
    1. Kessing LV, Vradi E, McIntyre RS, Andersen PK. Causes of decreased life expectancy over the life span in bipolar disorder. J Affect Disord. 2015;180:142–7. - PubMed
    1. Chan JKN, Correll CU, Wong CSM, et al. Life expectancy and years of potential life lost in people with mental disorders: A systematic review and meta-analysis. EClinicalMedicine. 2023. 10.1016/j.eclinm.2023.102294. - PMC - PubMed