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Review
. 2025:1471:285-299.
doi: 10.1007/978-3-031-77921-3_11.

Age-Related Thymic Involution

Marvin Paulo Lins  1   2 , Maria Danielma Dos Santos Reis  3   4
Affiliations
Review

Age-Related Thymic Involution

Marvin Paulo Lins et al. Adv Exp Med Biol. 2025.

Abstract

The age-related thymic involution has intrigued scientists since its first observations. This phenomenon is well-conserved across different species, but the reason why it exists is not clear since the thymus is a key organ in the immune system responsible for the maturation of immunocompetent T lymphocytes. As thymic function declines with age, it significantly affects the health of older individuals, leading to reduced responses to new pathogens, tumor cells, and vaccines. This impact was notably evident during the COVID-19 pandemic, where a substantial number of elderly individuals succumbed to the disease. This chapter explores the characteristics of age-related thymic involution, including new findings using recently developed technologies. We also highlight emerging research trends aimed at rejuvenating thymus function.

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References

    1. Aspinall R (1997) Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J Immunol 158:3037–3045. https://doi.org/10.4049/jimmunol.158.7.3037 - DOI - PubMed
    1. Aw D, Palmer DB (2012) It’s not all equal: a multiphasic theory of thymic involution. Biogerontology 13:77–81. https://doi.org/10.1007/s10522-011-9349-0 - DOI - PubMed
    1. Aw D, Silva AB, Maddick M et al (2008) Architectural changes in the thymus of aging mice. Aging Cell 7:158–167. https://doi.org/10.1111/j.1474-9726.2007.00365.x - DOI - PubMed
    1. Aw D, Taylor-Brown F, Cooper K, Palmer DB (2009) Phenotypical and morphological changes in the thymic microenvironment from ageing mice. Biogerontology 10:311–322. https://doi.org/10.1007/s10522-008-9182-2 - DOI - PubMed
    1. Aw D, Silva AB, Palmer DB (2010) The effect of age on the phenotype and function of developing thymocytes. J Comp Pathol 142(Suppl 1):S45–S59. https://doi.org/10.1016/j.jcpa.2009.10.004 - DOI - PubMed

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