Oral health benefits and safety of xylitol and potential cardiovascular risk: questioning the validity of the model of Witkowski et al

Gregory C Valentine^{1

2

3}, Eva Söderling⁴, Peter Milgrom³

Affiliations

¹ Department of Pediatrics, Division of Neonatology at University of Washington, 1959 NE Pacific St. Box 356320, RR542 HSB, Seattle, WA 98195-6320, USA.
² Department of Obstetrics & Gynecology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77401, USA.
³ Department of Oral Health Sciences at University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
⁴ Institute of Dentistry, University of Turku, Turku, Finland.

Gregory C Valentine et al. Eur Heart J. 2025.

. 2025 Jul 14;46(27):2705-2706.

doi: 10.1093/eurheartj/ehaf058.

Gregory C Valentine^{1

2

3}, Eva Söderling⁴, Peter Milgrom³

¹ Department of Pediatrics, Division of Neonatology at University of Washington, 1959 NE Pacific St. Box 356320, RR542 HSB, Seattle, WA 98195-6320, USA.
² Department of Obstetrics & Gynecology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77401, USA.
³ Department of Oral Health Sciences at University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
⁴ Institute of Dentistry, University of Turku, Turku, Finland.

No abstract available

References

1. Sen S, Logue L, Logue M, Otersen EAL, Mason E, Moss K, et al. Dental caries, race and incident ischemic stroke, coronary heart disease, and death. Stroke 2024;55:40–9. 10.1161/STROKEAHA.123.042528 - DOI - PMC - PubMed
1. Witkowski M, Nemet I, Li XS, Wilcox J, Ferrell M, Alamri H, et al. Xylitol is prothrombotic and associated with cardiovascular risk. Eur Heart J 2024;45:2439–52. 10.1093/eurheartj/ehae244 - DOI - PMC - PubMed
1. Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, et al. Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia. Neuroscience 2017;349:1–16. 10.1016/j.neuroscience.2017.02.036 - DOI - PubMed
1. Storey D, Lee A, Bornet F, Brouns F. Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid. Eur J Clin Nutr 2007;61:349–54. 10.1038/sj.ejcn.1602532 - DOI - PubMed
1. Bordier V, Teysseire F, Senner F, Schlotterbeck G, Drewe J, Beglinger C, et al. Absorption and metabolism of the natural sweeteners erythritol and xylitol in humans: a dose-ranging study. Int J Mol Sci 2022;23:9867. 10.3390/ijms23179867 - DOI - PMC - PubMed