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. 2025 May 7;46(18):1766-1768.
doi: 10.1093/eurheartj/ehaf118.

Epicardial adipose tissue and malignant ventricular arrhythmias in phospholamban p.(Arg14del) variant carriers

Belend Mahmoud  1 , Moniek G P J Cox  1 , Remco de Brouwer  2 , Myrthe Y C van der Heide  3 , Thomas M Gorter  1 , Laura M G Meems  1 , Arthur A M Wilde  3   4 , Dirk J van Veldhuisen  1 , Rudolf A de Boer  4   5 , B Daan Westenbrink  1
Affiliations

Epicardial adipose tissue and malignant ventricular arrhythmias in phospholamban p.(Arg14del) variant carriers

Belend Mahmoud et al. Eur Heart J. .
No abstract available

Keywords: Cardiomyopathy; Epicardial adipose tissue; Magnetic resonance imaging; Phospholamban; Ventricular arrhythmias.

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Figures

Figure 1
Figure 1
(A) Simplified graphical visualization of the methodology, showing population, EAT measurement on MRI, and outcome. Epicardial adipose tissue measurement is depicted on one short-axis cine stack of the heart on MRI, basal slice. Red/Bold: myocardial border. Green: visceral layer of the pericardium. The space in between represents EAT. (B) Forest plot showing (adjusted) HR for EAT univariably, EAT adjusted for factors influencing EAT volume (Model 1), EAT adjusted for factors in the contemporary MVA risk prediction model (Model 2), EAT adjusted for all variables in Models 1 + 2 using a backward selection process, with HR only reported for the covariates that remained significant after the backward selection (Model 3). (C) Receiver operating characteristic curve and Harrell’s C-statistic assessing the discriminative ability of EAT for MVA. The arrow indicates the optimal cut-off point based on the Youden index. (D) Kaplan–Meier curve showing the event-free survival of MVA in the primary cohort, stratified by EAT volume, using the optimal cut-off calculated shown in C. (E) Kaplan–Meier curve showing the event-free survival of MVA in the validation cohort, stratified by EAT volume, using the optimal cut-off calculated shown in C. PLN, phospholamban gene; EAT, epicardial adipose tissue; MRI, magnetic resonance imaging; MVA, malignant ventricular arrhythmia; BMI, body mass index; PVC, premature ventricular contraction; LVEF, left ventricular ejection fraction; HR, hazard ratio; CI, confidence interval; Adj.HR, adjusted hazard ratio
See this image and copyright information in PMC

References

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