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. 2025 Jun 1;15(2):189-190.
doi: 10.4103/mgr.MEDGASRES-D-24-00075. Epub 2024 Dec 7.

Risks of perturbed oxygen homeostasis: responses and adaptations to hyperoxia and hypoxia

Affiliations

Risks of perturbed oxygen homeostasis: responses and adaptations to hyperoxia and hypoxia

Johannes Burtscher et al. Med Gas Res. .
No abstract available

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Figures

Figure 1
Figure 1
Types of hypoxia and hypoxia/hyperoxia responses. Here, we discuss whether severe hyperoxia might overwrite (protective) responses and adaptations to hypoxia. Created with PowerPoint (Microsoft Office LTSC Professional Plus 2021). O2: Oxygen.

References

    1. Flanigan WR, Jain IH. The goldilocks oxygen principle: not too little and not too much. Nat Cardiovasc Res. 2022;1:1101–1103. - PMC - PubMed
    1. McIlroy DR, Shotwell MS, Lopez MG, et al. Oxygen administration during surgery and postoperative organ injury: observational cohort study. BMJ. 2022;379:e070941. - PMC - PubMed
    1. Martin J, Mazer-Amirshahi M, Pourmand A. The impact of hyperoxia in the critically ill patient: a review of the literature. Respir Care. 2020;65:1202–1210. - PubMed
    1. Terraneo L, Paroni R, Bianciardi P, et al. Brain adaptation to hypoxia and hyperoxia in mice. Redox Biol. 2017;11:12–20. - PMC - PubMed
    1. Burtscher J, Mallet RT, Pialoux V, Millet GP, Burtscher M. Adaptive responses to hypoxia and/or hyperoxia in humans. Antioxid Redox Signal. 2022;37:887–912. - PubMed

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