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Review
. 2025 Mar 11;4(3):pgaf030.
doi: 10.1093/pnasnexus/pgaf030. eCollection 2025 Mar.

Engineering and AI: Advancing the synergy

Affiliations
Review

Engineering and AI: Advancing the synergy

Ramalingam Chellappa et al. PNAS Nexus. .

Abstract

Recent developments in artificial intelligence (AI) and machine learning (ML), driven by unprecedented data and computing capabilities, have transformed fields from computer vision to medicine, beginning to influence culture at large. These advances face key challenges: accuracy and trustworthiness issues, security vulnerabilities, algorithmic bias, lack of interpretability, and performance degradation when deployment conditions differ from training data. Fields lacking large datasets have yet to see similar impacts. This paper examines AI and ML's growing influence on engineering systems-from self-driving vehicles to materials discovery-while addressing safety and performance assurance. We analyze current progress and challenges to strengthen the engineering-AI synergy.

Keywords: artificial intelligence; autonomous systems; ethics and responsibility; materials and manufacturing; robotics.

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References

    1. Davis W. Police pulled over a Waymo car for driving in the incoming lane. The Verge, 2024 Jul 6 [accessed 2024 Aug 1]. https://www.theverge.com/2024/7/6/24193094/phoenix-waymo-car-pulled-over....
    1. Siddiqui F, Merrill JB. 17 fatalities, 736 crashes: the shocking toll of Tesla's Autopilot. The Washington Post, 2023 Jun 10 [accessed 2024 Jul 1]. https://www.washingtonpost.com/technology/2023/06/10/tesla-autopilot-cra....
    1. Thadani T, Lerman R, Piper I, Siddiqui F, Uraizee I. The final 11 seconds of a fatal Tesla Autopilot crash. The Washington Post, 2023 Oct 6 [accessed 2024 Jul 1]. https://www.washingtonpost.com/technology/interactive/2023/tesla-autopil....
    1. Shneiderman B. 2020. Human-centered artificial intelligence: reliable, safe & trustworthy. Int J Hum Comput Interact. 36:495–504.
    1. Melnicuk V, Thompson S, Jennings P, Birrell S. 2021. Effect of cognitive load on drivers’ state and task performance during automated driving: introducing a novel method for determining stabilisation time following take-over of control. Accid Anal Prev. 151:105967. - PubMed

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