Consensus statement on the prevention, diagnosis, and management of infection following transcutaneous osseointegration for patients with limb loss: current state-of-the-art and proposed future studies
- PMID: 40071170
- PMCID: PMC11892711
- DOI: 10.1097/OI9.0000000000000369
Consensus statement on the prevention, diagnosis, and management of infection following transcutaneous osseointegration for patients with limb loss: current state-of-the-art and proposed future studies
Abstract
The diagnosis, risk factors, treatment algorithms, and long-term sequelae of superficial and deep, implant-related infections in transdermal, bone-anchored osseointegration are not well-defined. In contrast to the robust experience diagnosing and managing periprosthetic joint infections in total joint arthroplasty, osseointegration surgery has only recently been adopted at a small number of osseointegration centers in the United States, contributing to the lack of long-term outcomes. Through the pooled experience from these osseointegration centers, we present a consensus statement on the perioperative management, incidence, treatment, and diagnostic workup for infectious complications following transdermal, bone-anchored osseointegration.
Keywords: amputation; bone-anchored limb; infection; ossoeintegration; transdermal.
Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Orthopaedic Trauma Association.
Conflict of interest statement
Robert Rozbruch reports consulting fees from Nuvasive and J&J. He also reports having stock with Osteosys. Kyle Potter has a CDMRP PRORP grant/contract with DoD-USUHS Restoral. He also has consulting fees with Integrum and Signature. Dr. Hsu reports consultancy for Globus Medical and personal fees from Smith & Nephew speakers' bureau. Danielle Melton has DoD contract OP220013 and CDMRP Grant OR210169. She also has consulting fees for Paradigm Medical Director and has received payment for lectures at the State of the Science Conference on Osseointegration. Danielle Melton has received payment for expert testimony while acting as a consultant and expert witness in multiple cases. She has received support from Amputee Coalition BOD to travel and attend meetings. She has participated in the Data Safety Monitoring Advisory Board for External Advisory Panel for Limb Loss Prevention Registry. Danielle Melton has a leadership or fiduciary role in METRC Executive Council, Amputee Coalition Board of Directors, and in Catapult Board of Directors. Leah Gitajn received consulting fees from Stryker and Paragon28. She also has a leadership or fiduciary role in the OTA program committee and AO research committee. Jason Stoneback reports royalties from AQ Solutions as well as consulting fees from AQ Solutions and Smith and Nephew. He reports payment for lectures from Smith and Nephew and AQ Solutions. Jason Stoneback states he has received payment for expert testimony in multiple cases. He notes he has received support to travel and attend meetings from Smith and Nephew and AQ Solutions. He reports planning a patent for a Rotational Intramedullary Nail. Jason Stoneback states he is the secretary for ISPO Special Interest Group for Bone-Anchored Limbs and is a board member for Justin Sports Medicine Team Annual Conference. He also reports stock with Validus Cellular Therapeutics. Jason Souza is a paid consultant for Balmoral Medical, LLC, Checkpoint, Inc, and Integrum, Inc. The remaining authors declare they do not have any conflicts of interest.
Figures


References
-
- Hebert JS, Rehani M, Stiegelmar R. Osseointegration for lower-limb amputation: a systematic review of clinical outcomes. JBJS Rev. 2017;5:e10. - PubMed
-
- Brånemark R, Berlin O, Hagberg K, et al. . A novel osseointegrated percutaneous prosthetic system for the treatment of patients with transfemoral amputation: a prospective study of 51 patients. Bone Joint J. 2014;96-B:106–113. - PubMed
-
- Al Muderis M, Khemka A, Lord SJ, et al. . Safety of osseointegrated implants for transfemoral Amputees: a two-center prospective cohort study. J Bone Joint Surg Am. 2016;98:900–909. - PubMed
-
- Juhnke D-L, Beck JP, Jeyapalina S, et al. . Fifteen years of experience with integral-leg-prosthesis: cohort study of artificial limb attachment system. J Rehabil Res Dev. 2015;52:407–420. - PubMed
Publication types
LinkOut - more resources
Full Text Sources