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Comment
. 2025 Mar 11;58(3):525-528.
doi: 10.1016/j.immuni.2025.02.018.

RIPK3: The Deadpool of neuronal cell death proteins?

Clayton W Winkler  1 , Karin E Peterson  2
Affiliations
Comment

RIPK3: The Deadpool of neuronal cell death proteins?

Clayton W Winkler et al. Immunity. .

Abstract

Receptor interaction kinase 3 (RIPK3) is a key mediator of necroptosis, initiating programmed cell death with mercenary efficiency in multiple neurodegenerative diseases. However, in this issue of Immunity, Estevez et al. demonstrate that RIPK3, like the character Deadpool, exists in duality and can also be a force for good by preventing excitotoxic neuronal death during orthoflavivirus encephalitis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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