Immo-bile-izing CD8⁺ T cell anti-tumor immunity

Scott A Read¹, Golo Ahlenstiel²

Affiliations

¹ Blacktown Clinical School, Western Sydney University, Sydney, NSW 2148, Australia; Storr Liver Centre, Westmead Institute for Medical Research, Sydney, NSW 2145, Australia; Blacktown Mt Druitt Hospital, Sydney, NSW 2148, Australia.
² Blacktown Clinical School, Western Sydney University, Sydney, NSW 2148, Australia; Storr Liver Centre, Westmead Institute for Medical Research, Sydney, NSW 2145, Australia; Blacktown Mt Druitt Hospital, Sydney, NSW 2148, Australia. Electronic address: g.ahlenstiel@westernsydney.edu.au.

PMID: 40073845
DOI: 10.1016/j.immuni.2025.02.015

Immo-bile-izing CD8⁺ T cell anti-tumor immunity

Scott A Read et al. Immunity. 2025.

. 2025 Mar 11;58(3):532-534.

doi: 10.1016/j.immuni.2025.02.015.

Authors

Scott A Read¹, Golo Ahlenstiel²

Affiliations

¹ Blacktown Clinical School, Western Sydney University, Sydney, NSW 2148, Australia; Storr Liver Centre, Westmead Institute for Medical Research, Sydney, NSW 2145, Australia; Blacktown Mt Druitt Hospital, Sydney, NSW 2148, Australia.
² Blacktown Clinical School, Western Sydney University, Sydney, NSW 2148, Australia; Storr Liver Centre, Westmead Institute for Medical Research, Sydney, NSW 2145, Australia; Blacktown Mt Druitt Hospital, Sydney, NSW 2148, Australia. Electronic address: g.ahlenstiel@westernsydney.edu.au.

PMID: 40073845
DOI: 10.1016/j.immuni.2025.02.015

Abstract

Hepatocellular carcinoma is poorly responsive to immune checkpoint blockade. In a recent issue of Science, Varanasi et al. reveal how bile acids dampen anti-tumor CD8⁺ T cell responses in the liver, contributing to cancer progression and poor immunotherapy outcomes.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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- NCI CPTC Antibody Characterization Program

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Immo-bile-izing CD8⁺ T cell anti-tumor immunity

Affiliations

Immo-bile-izing CD8⁺ T cell anti-tumor immunity

Authors

Affiliations

Abstract

Conflict of interest statement

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials