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Editorial
. 2025 Mar 18;85(10):1015-1017.
doi: 10.1016/j.jacc.2025.01.008.

Transthyretin Amyloid Cardiomyopathy: Wherever Protein Stabilization Leads, Disease Stabilization Follows

Justin L Grodin  1
Affiliations
Editorial

Transthyretin Amyloid Cardiomyopathy: Wherever Protein Stabilization Leads, Disease Stabilization Follows

Justin L Grodin. J Am Coll Cardiol. .
No abstract available

Keywords: acoramidis; amyloidosis; tafamidis; transthyretin.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Grodin has received personal fees from Pfizer, Alnylam, Eidos/BridgeBio, AstraZeneca, Alexion, Lumanity, Novo Nordisk, Ultromics, Tenax Therapeutics, and Intellia; and has received grant support from the National Heart, Lung, and Blood Institute, Pfizer, Eidos/BridgeBio, and the Texas Health Resources Clinical Scholars Fund.

Comment on

References

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    1. Maurer MS, Schwartz JH, Gundapaneni B et al. Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. N Engl J Med 2018;379:1007–1016. - PubMed
    1. Gillmore JD, Judge DP, Cappelli F et al. Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy. N Engl J Med 2024;390:132–142. - PubMed
    1. Penchala SC, Connelly S, Wang Y et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A 2013;110:9992–7. - PMC - PubMed
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