Bispecific antibody therapy for lymphoma

Abstract

The rapid development of novel therapeutics in B-cell Non-Hodgkin's lymphoma (B-NHL) over the past decade has presented a critical inflection point for the field. Bispecific antibodies are one such therapeutic class emerging as an effective, off-the-shelf option for B-NHL. In this review, we focus primarily on Diffuse Large B-cell Lymphoma (DLBCL), highlighting the evolution, comparison, tolerability, ongoing challenges, and future potential of bispecific antibodies that are currently approved or in clinical trials for B-NHL. With the number of anti-lymphoma drugs increasing every year, it is important to optimize clinical trial analysis and design so that outcomes, toxicities, and predictors thereof can be understood and compared amongst therapeutic classes to ensure that patients get the safest and most effective treatments for them at the most appropriate line of therapy.

Keywords: B-Cell Non-Hodgkin's lymphoma; Bispecific T-cell engager; Bispecific antibody; Diffuse large B-Cell lymphoma; Immune therapy; Immunotherapy; Lymphoma.