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Case Reports
. 1985 Jun;26(6):636-8.
doi: 10.1136/gut.26.6.636.

Ketoconazole-induced fulminant hepatitis

E Bercoff, J Bernuau, C Degott, B Kalis, A Lemaire, H Tilly, B Rueff, J P Benhamou
Case Reports

Ketoconazole-induced fulminant hepatitis

E Bercoff et al. Gut. 1985 Jun.

Abstract

We report the cases of two adult patients in whom fulminant hepatitis developed after 17 and 103 days of ketoconazole administration. Histologic administration showed massive, predominantly centrilobular necrosis. Clinical manifestations of hypersensitivity and eosinophilia were absent in both patients, which suggests that ketoconazole hepatotoxicity is not mediated through an immunoallergic mechanism.

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References

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