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Review
. 2025 Feb 21;26(5):1863.
doi: 10.3390/ijms26051863.

A Closer Look into Autoimmune Liver Diseases

Branka Filipovic  1   2 , Marija Marjanovic-Haljilji  1 , Dragana Blagojevic  1 , Milica Dragovic  1 , Emilija Krsmanovic  1 , Ana Matovic  3 , Natasa Panic  1 , Stanimir Kiurski  1 , Zagor Zagorac  4 , Miljan Milanovic  2   4 , Olivera Markovic  2   5 , Aleksandra Djokovic  2   6 , Tijana Glisic  2   7 , Sanja Dragasevic  2   7 , Dusan Popovic  1   2
Affiliations
Review

A Closer Look into Autoimmune Liver Diseases

Branka Filipovic et al. Int J Mol Sci. .

Abstract

Autoimmune liver diseases involve a heterogeneous group of chronic inflammatory disorders, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Sometimes presented consistently as an overlapping syndrome, their pathogenesis is rather complex and has yet to be fully elucidated, despite extensive research efforts. This review article corroborates the molecular mechanisms of autoimmune liver diseases, as well as existing and potential therapeutic modalities.

Keywords: autoimmune liver disease; hepatitis; primary biliary cholangitis; primary sclerosing cholangitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Pathogenesis of AIH. Abbreviations: HLA—human leukocyte antigen; EBV—Epstein–Barr virus; CMV—cytomegalovirus.
See this image and copyright information in PMC

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